Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.69 extracted from

  • Serpa, J.; Mendes, N.; Reis, C.A.; Santos Silva, L.F.; Almeida, R.; Le Pendu, J.; David, L.
    Two new FUT2 (fucosyltransferase 2 gene) missense polymorphisms, 739G-->A and 839T-->C, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal (2004), Biochem. J., 383, 469-474.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
F280S missense polymorphism, almost inactive enzyme, responsible for some non-secretor cases Homo sapiens
G247S missense polymorphism, almost inactive enzyme, responsible for some non-secretor case Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information KM-value for asialofetuin: 3.33 mg/ml Homo sapiens
0.05
-
GDP-fucose pH 6.0, 37°C. wild-type enzyme Homo sapiens
0.0909
-
GDP-fucose pH 6.0, 37°Cmutant enzyme F280SS Homo sapiens
0.178
-
GDP-fucose pH 6.0, 37°C, mutant enzyme G247S Homo sapiens
8.79
-
phenyl beta-D-galactoside pH 6.0, 37°C. wild-type enzyme Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
two fucosyltransferase 2 gene missense polymorphisms, G247S and F280S, are partly responsible for non-secretor status in a Caucasian population from Northern Portugal
-

Source Tissue

Source Tissue Comment Organism Textmining
blood
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-fucose + asialofetuin
-
Homo sapiens GDP + asialofetuin
-
?

Synonyms

Synonyms Comment Organism
fucosyltransferase 2
-
Homo sapiens
FUT2
-
Homo sapiens