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Literature summary for 2.4.1.68 extracted from

  • Bany-Laszewicz, U.; Kaminska, J.; Klimczak-Jajor, E.; Koscielak, J.
    The activity of alpha1,6-fucosyltransferase during human megakaryocytic differentiation (2004), Cell. Mol. Biol. Lett., 9, 145-152.
    View publication on PubMed

Application

Application Comment Organism
medicine the enzyme is a candidate for the earliest marker of megakaryocyte-commitment in cultured hematopoietic stem cells. Such a marker should allow an earlier detection and earlier transplantation of patients own, ex vivo expanded, megakaryocyte progenitors Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa (CD41a) which is present in megakaryocytes and platelets ?
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?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
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Source Tissue

Source Tissue Comment Organism Textmining
blood platelet heavy load of 6FucT Homo sapiens
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hematopoietic stem cell CD34+ cell, activity of 6FucT increases ahead of, and thereafter concomitantly with, cells expressing the CD41a antigen. When the CD41a+ subpopulation of cells is immunoselected (using anti-CD61 i.e. anti GpIIIa antibodies), its 6FucT activity increases proportionally to the yield of DC61+ cells Homo sapiens
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megakaryocyte heavy load of 6FucT Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information one of the enzymes involved in the synthesis of N-linked glycans of the GpIIb/IIIa (CD41a) which is present in megakaryocytes and platelets Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
6FucT
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Homo sapiens
alpha1,6-fucosyltransferase
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Homo sapiens