Application | Comment | Organism |
---|---|---|
medicine | high enzyme expression in breast cancer biopsies is associated with increased risk of mortality | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine | Homo sapiens | - |
UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O00469 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MDA-MB-231 cell | - |
Homo sapiens | - |
MDA-MB-435 cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-alpha-D-galactose + procollagen 5-hydroxy-L-lysine | - |
Homo sapiens | UDP + procollagen 5-(D-galactosyloxy)-L-lysine | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PLOD2 | - |
Homo sapiens |
procollagen lysyl hydroxylase 2 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | PLOD2 mRNA is induced greater than 4fold by hypoxia within 12 h and remains elevated for 72 hours of continuous hypoxia | up |
General Information | Comment | Organism |
---|---|---|
malfunction | enzyme knockdown in breast cancer cells inhibits local tissue invasion | Homo sapiens |
metabolism | procollagen lysyl hydroxylase 2 is required for the biogenesis of collagen | Homo sapiens |
physiological function | procollagen lysyl hydroxylase 2 is essential for hypoxia-induced breast cancer metastasis. The enzyme is critical for fibrillary collagen formation by breast cancer cells, increases tumor stiffness, and is required for metastasis to lymph nodes and lungs | Homo sapiens |