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Literature summary for 2.4.1.5 extracted from

  • Goyal, D.; Sharma, S.; Mahmood, A.
    Inhibition of dextransucrase activity in Streptococcus mutans by plant phenolics (2013), Indian J. Biochem. Biophys., 50, 48-53.
    View publication on PubMed
Search for more literature for 2.4.1.5

Inhibitors

Inhibitors Comment Organism Structure
gallic acid 80-90% inhibition at 4-5 mM, mixed-type inhibition in vitro Streptococcus mutans
additional information aqueous plant extracts from wood sticks of Acacia arabica, Azadirachta indica, Pongamia pinnata, and Salvadora persica are inhibitory. 5 mg Phenolic content in aqueous extracts of chewing stem sticks produce 35-40% inhibition of the enzyme activity, best inhibition at 7-7.5 for the phenolic compounds, and at pH 5.0-6.0 for plant extracts Streptococcus mutans
syringic acid 48% inhibition at 5 mM, mixed-type inhibition in vitro Streptococcus mutans
Tannic acid 80% inhibition at 0.2 mM, mixed-type inhibition in vitro Streptococcus mutans

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Streptococcus mutans
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
sucrose + [(1->6)-alpha-D-glucosyl]n Streptococcus mutans
-
 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?
sucrose + [(1->6)-alpha-D-glucosyl]n Streptococcus mutans MTCC 890
-
 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans
-
-
-
Streptococcus mutans MTCC 890
-
-
-

Purification (Commentary)

Purification (Comment) Organism
native enzyme from cell-free extracts by gel filtration Streptococcus mutans

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme shows hydrolytic and glucosyl transferase activities with sucrose Streptococcus mutans ?
-
 ?
additional information the enzyme shows hydrolytic and glucosyl transferase activities with sucrose Streptococcus mutans MTCC 890 ?
-
 ?
sucrose + [(1->6)-alpha-D-glucosyl]n
-
 Streptococcus mutans D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?
sucrose + [(1->6)-alpha-D-glucosyl]n
-
 Streptococcus mutans MTCC 890 D-fructose + [(1->6)-alpha-D-glucosyl]n+1
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Streptococcus mutans

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.8
-
 assay at Streptococcus mutans

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.35
-
 Tannic acid pH 6.8, 37°C Streptococcus mutans
1.6
-
 gallic acid pH 6.8, 37°C Streptococcus mutans
1.94
-
 syringic acid pH 6.8, 37°C Streptococcus mutans

General Information

General Information Comment Organism
metabolism the enzyme is responsible for sucrose metabolism exhibiting both hydrolysis and glucosyl transferase activities Streptococcus mutans
physiological function Streptococcus mutans causes dental caries in humans using sucrose for its growth Streptococcus mutans