Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary for 2.4.1.41 extracted from

  • Wang, Z.Q.; Bachvarova, M.; Morin, C.; Plante, M.; Gregoire, J.; Renaud, M.C.; Sebastianelli, A.; Bachvarov, D.
    Role of the polypeptide N-acetylgalactosaminyltransferase 3 in ovarian cancer progression: possible implications in abnormal mucin O-glycosylation (2014), Oncotarget, 5, 544-560.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine isoform GALNT3 expression significantly correlates with shorter progression-free survival intervals in epithelial ovarian cancer patients with advanced disease Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1 Homo sapiens
-
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
A-2780 cell
-
Homo sapiens
-
serous adenocarcinoma cell
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1
-
Homo sapiens UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1
-
?

Synonyms

Synonyms Comment Organism
GALNT3
-
Homo sapiens
polypeptide N-acetylgalactosaminyltransferase 3
-
Homo sapiens

Expression

Organism Comment Expression
Homo sapiens isoform GALNT3 is strongly overexpressed in high-grade serous epithelial ovarian tumors as compared to normal ovarian tissue up

General Information

General Information Comment Organism
malfunction knockdown of the isoform GALNT3 expression in epithelial ovarian cancer cells leads to sharp decrease of cell proliferation and induced S-phase cell cycle arrest. Additionally, GALNT3 suppression significantly inhibits epithelial ovarian cancer cell migration and invasion. GALNT3 knockdown is also accompanied with increase of the cell adhesion molecules beta-catenin and E-cadherin Homo sapiens