Application | Comment | Organism |
---|---|---|
medicine | isoform GALNT3 expression significantly correlates with shorter progression-free survival intervals in epithelial ovarian cancer patients with advanced disease | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1 | Homo sapiens | - |
UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
A-2780 cell | - |
Homo sapiens | - |
serous adenocarcinoma cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-alpha-D-galactosamine + polypeptide Muc1 | - |
Homo sapiens | UDP + N-acetyl-alpha-D-galactosaminyl-polypeptide Muc1 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
GALNT3 | - |
Homo sapiens |
polypeptide N-acetylgalactosaminyltransferase 3 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | isoform GALNT3 is strongly overexpressed in high-grade serous epithelial ovarian tumors as compared to normal ovarian tissue | up |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of the isoform GALNT3 expression in epithelial ovarian cancer cells leads to sharp decrease of cell proliferation and induced S-phase cell cycle arrest. Additionally, GALNT3 suppression significantly inhibits epithelial ovarian cancer cell migration and invasion. GALNT3 knockdown is also accompanied with increase of the cell adhesion molecules beta-catenin and E-cadherin | Homo sapiens |