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Literature summary for 2.4.1.41 extracted from

  • Elhammer, A.P.; Poorman, R.A.; Brown, E.; Maggiora, L.L.; Hoogerheide, J.G.; Kezdy, F.J.
    The specificity of UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase as inferred from a database of in vivo substrates and from the in vitro glycosylation of proteins and peptides (1993), J. Biol. Chem., 268, 10029-10038.
    View publication on PubMed
Search for more literature for 2.4.1.41

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
3.3
-
 Arg-Thr-Pro-Pro-Pro derived from the major acceptor sequence in myelin basic protein Bos taurus
6
-
 Pro-Pro-Ala-Ser-Thr-Ser-Ala-Pro-Gly
-
 Bos taurus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-galactosamine + polypeptide Bos taurus catalyzes in vivo glycosylation of both threonine and serine UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?

Organism

Organism UniProt Comment Textmining
Bos taurus
-
 colostrum
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information not: bovine cytochrome c Bos taurus ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Arg-Thr-Pro-Pro-Pro
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-alpha-D-galactosamine + Pro-Pro-Ala-Ser-Thr-Ser-Ala-Pro-Gly
-
 Bos taurus ?
-
 ?
UDP-N-acetyl-D-galactosamine + apomucin bovine apomucin Bos taurus UDP + N-acetyl-D-galactosaminyl-apomucin
-
 ?
UDP-N-acetyl-D-galactosamine + myelin basic protein
-
 Bos taurus UDP + N-acetyl-D-galactosaminyl-myelin basic protein
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide broad specificity, acceptors: unglycosylated protein acceptors, synthetic peptides, O-glycosylates threonine about 35times faster than serine, specificity is determined by the amino acids in the acceptor peptide segment and its accessibility, enzymatic active site interacts with an 8-amino acid long segment of the substrate, spanning 3 amino acids preceding and 4 amino acids following the reactive Thr or Ser Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + polypeptide catalyzes in vivo glycosylation of both threonine and serine Bos taurus UDP + N-acetyl-D-galactosaminyl-polypeptide
-
 ?
UDP-N-acetyl-D-galactosamine + rhodanese reduced and carboxylmethylated bovine rhodanese, at a lower rate than with myelin basic protein Bos taurus UDP + N-acetyl-D-galactosaminyl-rhodanese
-
 ?
UDP-N-acetyl-D-galactosamine + subtilisin reduced and carboxylmethylated bacterial subtilisin, at a lower rate than with myelin basic protein or bovine rhodanese Bos taurus UDP + N-acetyl-D-galactosaminyl-subtilisin
-
 ?