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Literature summary for 2.4.1.41 extracted from
- Characterization of a UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase that displays glycopeptide N-acetylgalactosaminyltransferase activity (1999), J. Biol. Chem., 274, 27867-27874.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| amino acid sequences of ppGaNTase-T3 and T4 | Mus musculus |
| ppGaNTase-T6 from sublingual gland is cloned, sequenced and expressed transiently in COS7 cells as secreted form, 657-amino acid protein, amino acid sequences of ppGaNTase-T1, -T5 and -T6 | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| membrane | - |
Mus musculus | 16020 | - |
| membrane | ppGaNTase-T6: type II membrane protein with a 27-amino acid hydrophobic region | Rattus norvegicus | 16020 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| UDP-N-acetyl-D-galactosamine + polypeptide | Mus musculus | initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? |  |
| UDP-N-acetyl-D-galactosamine + polypeptide | Rattus norvegicus | initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | Mus musculus | O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | Rattus norvegicus | O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | - |
BALB/c mouse, ppGaNTase-T6, -T1 and -T4 | - |
| Rattus norvegicus | Q9R0C5 | Wistar rats, ppGaNTase-T6, -T1 and -T4 | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| colon | ppGaNTase-T6 | Mus musculus | - |
| colon | ppGaNTase-T6 | Rattus norvegicus | - |
| additional information | traces of ppGaNTase-T6 in the ovary, cervix and uterus, ppGaNTase-T1 is present in all tissues examined | Mus musculus | - |
| additional information | traces of ppGaNTase-T6 in the ovary, cervix and uterus, ppGaNTase-T1 is present in all tissues examined | Rattus norvegicus | - |
| small intestine | ppGaNTase-T6 | Mus musculus | - |
| small intestine | ppGaNTase-T6 | Rattus norvegicus | - |
| stomach | ppGaNTase-T6 | Mus musculus | - |
| stomach | ppGaNTase-T6 | Rattus norvegicus | - |
| sublingual gland | ppGaNTase-T6: highest level of mRNA | Mus musculus | - |
| sublingual gland | ppGaNTase-T6: highest level of mRNA | Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | multiple enzyme isoforms | Mus musculus | ? | - |
? | |
| additional information | multiple enzyme isoforms | Rattus norvegicus | ? | - |
? | |
| additional information | ppGaNTase-T6: no activity with unglycosylated peptides | Rattus norvegicus | ? | - |
? | |
| UDP-N-acetyl-D-galactosamine + GalNAc-glycosylated peptide | ppGaNTase-T6 requires at least 2 intact GalNAc residues in the substrate, acceptor: MUC5AC-glycopeptide, obtained by the action of ppGaNTase-T1 | Rattus norvegicus | UDP + N-acetyl-D-galactosaminyl-GalNAc-glucosylated peptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | - |
Mus musculus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | ppGaNTase-T1: acceptor is MUC5AC peptide, di-glycopeptide contains GalNAc at Thr-3 and -13, tri-glycopeptide an additional one at Ser-5 | Rattus norvegicus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function | Mus musculus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | initiation of mucin-type O-glycosylation by a family of polypeptide GalNAc-transferases, of which each has a unique function | Rattus norvegicus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner | Mus musculus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
| UDP-N-acetyl-D-galactosamine + polypeptide | O-glycosylation by ppGaNTase-Ts of multisite substrates may proceed in a specific hierarchical manner | Rattus norvegicus | UDP + N-acetyl-D-galactosaminyl-polypeptide | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 37 | - |
assay at | Mus musculus |
| 37 | - |
assay at | Rattus norvegicus |
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