Application | Comment | Organism |
---|---|---|
pharmacology | beta 1,4GalT V inhibitors enhance the therapeutic effect of As2O3 for malignant glioma | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | beta 1,4GalT V antisense constructs interfere with beta 1,4GalT V leading to promotion of As2O3-induced glioma cell apoptosis, while overexpression of beta 1,4GalT V inhibits it, overview | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | As2O3 significantly decreases beta 1,4GalT V expression level in in glioma cells, which increases the glioma cell apoptosis induced by As2O3, overviewoverview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Renatured (Comment) | Organism |
---|---|
expression of HA-tagged beta 1,4GalT V | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
glioma cell | - |
Homo sapiens | - |
SHG-44 cell | - |
Homo sapiens | - |
U-251 cell | - |
Homo sapiens | - |
U-87MG cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | beta 1,4GalT V galactosylates the beta1,6-GlcNAc branch of N-glycans at the cell surface and of secreted glycoproteins, and functions as a positive regulator in glioma development, overview. As2O3-induced gioma cell apoptosis mechanism involves beta 1,4GalT V inhibition, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta 1,4GalT V | - |
Homo sapiens |