Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | development and synthesis of mechanism-based inhibitors, structure analysis, overview | Homo sapiens | |
uridine 5'-(6-amino-(2-[(7-bromomethyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate | irreversible, modifies residue Trp310 | Homo sapiens | |
uridine 5'-(6-amino-(2-[(7-methyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate | - |
Homo sapiens | |
uridine 5'-(6-O-[10-(2-naphthyl)-3,6,9-trioxadecanyl]-alpha-D-galactopyranosyl)diphosphate | competitive versus UDP-Gal, blocks acceptor substrate binding by the enzyme in presence of Mn2+ | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00491 | - |
UDP-Gal | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mn2+ | - |
Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | Homo sapiens | - |
UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
UDP-alpha-D-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-(1->4)-N-acetyl-beta-D-glucosaminylglycopeptide | functional role of Trp310 residue located in the small loop near the active site of the enzyme | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | - |
Homo sapiens | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? | |
UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide | UDP-Gal-Mn2+ substrate binding structure, overview | Homo sapiens | UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide | - |
? |
Synonyms | Comment | Organism |
---|---|---|
beta1,4-galactosyltransferase | - |
Homo sapiens |
betaGalT-1 | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.5 | - |
assay at | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00186 | - |
uridine 5'-(6-O-[10-(2-naphthyl)-3,6,9-trioxadecanyl]-alpha-D-galactopyranosyl)diphosphate | - |
Homo sapiens | |
0.0223 | - |
uridine 5'-(6-amino-(2-[(7-methyl-2-naphthyl)methoxycarbonylmethoxy]ethoxy)acetyl-6-deoxy-alpha-D-galactopyranosyl) diphosphate | - |
Homo sapiens |