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Literature summary for 2.4.1.37 extracted from
- Generation of histo-blood group B transferase by replacing the N-acetyl-D-galactosamine recognition domain of human A transferase with the galactose-recognition domain of evolutionarily related murine alpha1,3-galactosyltransferase (2009), Transfusion, 50, 622-630.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression of wild-type and chimeric mutant enzyme in HeLa cells | Homo sapiens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | generation of a structural chemira of histo-blood group B transferase, a B type transferase, by replacing the N-acetyl-D-galactosamine recognition domain of human type A transferase with the galactose-recognition domain of evolutionarily related murine alpha1,3-galactosyltransferase, leading to functional conversion from human A to B transferase activity, overview. When the glycine 268 of the A transferase is substituted by the alanine of the B transferase, the construct expresses an enzyme with weak B transferase activity, but when the alanine 268 of B transferase is substituted by the glycine of A transferase, the construct expresses an enzyme with strong A and B transferase activity | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | histo-blood group B transferase transfers alpha-D-galatose to the antigen,H, while the B type enzyme transfers N-acetylgalactosamine, overview | ? | - |
? |  |
| UDP-galactose + blood group antigen H | Homo sapiens | the alpha1,3-galactosyl epitope is a major xenotransplant antigen | UDP + alpha-D-galactosyl-blood group antigen H | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | histo-blood group B transferase transfers alpha-D-galatose to the antigen,H, while the B type enzyme transfers N-acetylgalactosamine, overview | Homo sapiens | ? | - |
? | |
| UDP-galactose + blood group antigen H | the alpha1,3-galactosyl epitope is a major xenotransplant antigen | Homo sapiens | UDP + alpha-D-galactosyl-blood group antigen H | - |
? | |
| UDP-galactose + blood group antigen H | alpha-L-fucosyl-(1,2)-D-galactosyl-antigen H | Homo sapiens | UDP + alpha-D-galactosyl-blood group antigen H | alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl(1,2)]-D-galactosyl-antigen H | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| B transferase | - |
Homo sapiens |
| histo-blood group B transferase | - |
Homo sapiens |
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