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Literature summary for 2.4.1.37 extracted from

  • Hosseini-Maaf, B.; Letts, J.A.; Persson, M.; Smart, E.; LePennec, P.; Hustinx, H.; Zhao, Z.; Palcic, M.M.; Evans, S.V.; Chester, M.A.; Olsson, M.L.
    Structural basis for red cell phenotypic changes in newly identified, naturally occurring subgroup mutants of the human blood group B glycosyltransferase (2007), Transfusion, 47, 864-875.
    View publication on PubMed

Cloned(Commentary)

Cloned (Comment) Organism
gene ABO, DNA and amino acid sequence determination and analysis of different allelic variants, blood group genotyping Homo sapiens

Crystallization (Commentary)

Crystallization (Comment) Organism
wild-type and mutant enzymes, X-ray diffraction structure determination and analysis at 1.99 A resolution, modelling Homo sapiens

Protein Variants

Protein Variants Comment Organism
A268T naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
A268T naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
D262N naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
D262N naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
F216I naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
F216I naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
I192T naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
I192T naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
M189V naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
M189V naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview Homo sapiens
additional information identification of naturally occruing polymorphisms in the ABO gene, phenotypes, overview Homo sapiens
additional information identification of naturally occurring polymorphisms in the ABO gene, phenotypes, overview Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics of wild-type and mutant enzymes Homo sapiens
0.027
-
UDP-galactose wild-type enzyme Homo sapiens
0.042
-
UDP-galactose mutant D262N Homo sapiens
0.052
-
UDP-galactose mutant F216I Homo sapiens
0.222
-
UDP-galactose mutant A268T Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cell surface
-
Homo sapiens 9986
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R Homo sapiens
-
UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens A5X6H3 fragment; ABO gene
-
Homo sapiens A5X6H4 fragment; ABO gene
-
Homo sapiens A5X6H5 fragment; ABO gene
-
Homo sapiens A5X6H7 fragment; ABO gene
-
Homo sapiens A5X6H8 fragment; ABO gene
-
Homo sapiens Q6L638 fragment; ABO gene
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R
-
Homo sapiens UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R
-
?

Subunits

Subunits Comment Organism
More three-dimensional structure molecular modeling of wild-type and mutant enzymes Homo sapiens

Synonyms

Synonyms Comment Organism
blood group B glycosyltransferase
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.039
-
UDP-galactose mutant A268T Homo sapiens
2
-
UDP-galactose mutant F216I Homo sapiens
2.5
-
UDP-galactose mutant D262N Homo sapiens
5.1
-
UDP-galactose wild-type enzyme Homo sapiens