Cloned (Comment) | Organism |
---|---|
gene ABO, DNA and amino acid sequence determination and analysis of different allelic variants, blood group genotyping | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
wild-type and mutant enzymes, X-ray diffraction structure determination and analysis at 1.99 A resolution, modelling | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
A268T | naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
A268T | naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
D262N | naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
D262N | naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
F216I | naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
F216I | naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
I192T | naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
I192T | naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
M189V | naturally occuring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
M189V | naturally occurring mutant from individuals with weak B phenotype showing serologically weak B antigen on their red cells, overview | Homo sapiens |
additional information | identification of naturally occruing polymorphisms in the ABO gene, phenotypes, overview | Homo sapiens |
additional information | identification of naturally occurring polymorphisms in the ABO gene, phenotypes, overview | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetics of wild-type and mutant enzymes | Homo sapiens | |
0.027 | - |
UDP-galactose | wild-type enzyme | Homo sapiens | |
0.042 | - |
UDP-galactose | mutant D262N | Homo sapiens | |
0.052 | - |
UDP-galactose | mutant F216I | Homo sapiens | |
0.222 | - |
UDP-galactose | mutant A268T | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
cell surface | - |
Homo sapiens | 9986 | - |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R | Homo sapiens | - |
UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | A5X6H3 | fragment; ABO gene | - |
Homo sapiens | A5X6H4 | fragment; ABO gene | - |
Homo sapiens | A5X6H5 | fragment; ABO gene | - |
Homo sapiens | A5X6H7 | fragment; ABO gene | - |
Homo sapiens | A5X6H8 | fragment; ABO gene | - |
Homo sapiens | Q6L638 | fragment; ABO gene | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
erythrocyte | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-galactose + alpha-L-fucosyl-(1,2)-D-galactosyl-R | - |
Homo sapiens | UDP + alpha-D-galactosyl-(1,3)-[alpha-L-fucosyl-(1,2)]-D-galactosyl-R | - |
? |
Subunits | Comment | Organism |
---|---|---|
More | three-dimensional structure molecular modeling of wild-type and mutant enzymes | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
blood group B glycosyltransferase | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.039 | - |
UDP-galactose | mutant A268T | Homo sapiens | |
2 | - |
UDP-galactose | mutant F216I | Homo sapiens | |
2.5 | - |
UDP-galactose | mutant D262N | Homo sapiens | |
5.1 | - |
UDP-galactose | wild-type enzyme | Homo sapiens |