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Literature summary for 2.4.1.344 extracted from

  • Basu, S.; Basu, M.; Chien, J.L.
    Enzymatic synthesis of a blood group H-related glycosphingolipid by an alpha-fucosyltransferase from bovine spleen (1975), J. Biol. Chem., 250, 2956-2962.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
G-3634-A cationic detergent, optimal rate of reaction at 5 mg/ml Bos taurus
taurocholate about 36% as effective as G-3634-A Bos taurus

Inhibitors

Inhibitors Comment Organism Structure
EDTA 5 mM, 5% residual activtiy Bos taurus
GTP 0.5 mM, 30% inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.36
-
beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-glucosylceramide pH 6.4, 37°C Bos taurus
0.6
-
GDP-beta-L-fucose pH 6.4, 37°C Bos taurus

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum
-
Bos taurus 5783
-
membrane
-
Bos taurus 16020
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ 50-70% recovery of activity after EDTA-treatment Bos taurus
Mn2+ 50-70% recovery of activity after EDTA-treatment Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
spleen
-
Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
GDP-beta-L-fucose + beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-glucosylceramide
-
Bos taurus GDP + alpha-L-fucosyl-(1->2)-beta-D-galactosyl-(1->4)-N-acetyl-D-glucosaminyl-(1->3)-beta-D-galactosyl-(1->4)-glucosylceramide
-
?
additional information enzyme catalyzes the transfer of L-fucose from GDP-L-fucose to a tetraglycosylceramide to form the blood group H-related glycosphingolipid Bos taurus ?
-
?
additional information no substrates: glucosamine, UDP-N-acetyl-galactosamine, and CMP-sialic acid Bos taurus ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4
-
cacodylate buffer Bos taurus