Literature summary for 2.4.1.316 extracted from

Gaisser, S.; Reather, J.; Wirtz, G.; Kellenberger, L.; Staunton, J.; Leadlay, P.F.
A defined system for hybrid macrolide biosynthesis in Saccharopolyspora erythraea (2000), Mol. Microbiol., 36, 391-401.

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Organism

Organism	UniProt	Comment	Textmining
Streptomyces fradiae	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
tylactone + dTDP-D-desosaminose	-	Streptomyces fradiae	dTDP + 5-O-desosaminyl-tylactone	-	?

General Information

General Information	Comment	Organism
physiological function	expression of the mycaminosyltransferase TylM2 from Streptomyces fradiae in Saccharopolyspora erythraea SGT2 lacking both eryBV and eryCIII genes encoding the respective glycosyltransferase genes and glycosyltransferase OleG2. Feeding of the resulting strain with the 16-membered aglycone tylactone, the normal TylM2 substrate, leads to formation of a new hybrid glycoside; 5-O-desosaminyl-tylactone	Streptomyces fradiae

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Release 2023.1 (January 2023)