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Literature summary for 2.4.1.293 extracted from

  • Kelly, J.; Jarrell, H.; Millar, L.; Tessier, L.; Fiori, L.M.; Lau, P.C.; Allan, B.; Szymanski, C.M.
    Biosynthesis of the N-linked glycan in Campylobacter jejuni and addition onto protein through block transfer (2006), J. Bacteriol., 188, 2427-2434.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.293

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol Campylobacter jejuni
-
 UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol Campylobacter jejuni NCTC 11168
-
 UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Organism

Organism UniProt Comment Textmining
Campylobacter jejuni
-
 gene pglI, in gene cluster, cj1119c-cj1131c
-
Campylobacter jejuni NCTC 11168
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 gene pglI, in gene cluster, cj1119c-cj1131c
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 Campylobacter jejuni UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 ?
UDP-alpha-D-glucose + [GalNAc-alpha-(1->4)]4-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 Campylobacter jejuni NCTC 11168 UDP + [GalNAc-alpha-(1->4)]2-[Glc-beta-(1->3)]-[GalNAc-alpha-(1->4)]2-GalNAc-alpha-(1->3)-Bac2,4diNAc-diphospho-tritrans,heptacis-undecaprenol
-
 ?

Synonyms

Synonyms Comment Organism
PglI
-
 Campylobacter jejuni

General Information

General Information Comment Organism
malfunction pglI mutation causes loss of the glucose branch, the Glc transferase mutant pglI/kpsM is still able to synthesize a glycan, structure of the N-linked glycan from the pglI mutant by NMR analysis, overview. The oligosaccharide transferred in the pglI mutant contains the entire 6-mer, demonstrating that Glc plays no role in determining the length of the GalNAc backbone Campylobacter jejuni
metabolism PglI acts in the Campylobacter jejuni N-glycan biosynthesis, it is the glucosyltransferase and the putative ABC transporter, N-glycan pathway, overview Campylobacter jejuni