Organism | UniProt | Comment | Textmining |
---|---|---|---|
Drosophila melanogaster | Q9VQB7 | - |
- |
Homo sapiens | Q5NDL2 | - |
- |
Synonyms | Comment | Organism |
---|---|---|
EGF domain-specific O-linked N-acetylglucosamine transferase | - |
Drosophila melanogaster |
EGF domain-specific O-linked N-acetylglucosamine transferase | - |
Homo sapiens |
EOGT | - |
Drosophila melanogaster |
EOGT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | Eogt may regulate protein functions by O-GlcNAc modification of their EGF repeats, and cellular metabolism by affecting pyrimidine synthesis and catabolism. Eogt knock-down in the wing leads to metabolic and signaling perturbations that increase cytosolic uracil levels, thereby causing wing blister formation | Drosophila melanogaster |
physiological function | transfection of human EOGT cDNA causes O-GlcNAcylation of Drosphila N, Dl and Ser EGF repeats. EOGT requires a conserved DXD motif for optimal activity, and it is primarily responsible for the transfer of OGlcNAc to high molecular weight proteins, including Dp, in Drosophila larvae. In vivo, the human EOGT cDNA fully rescues homozygotes of a P-element excision mutation of EOGT | Homo sapiens |