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Literature summary for 2.4.1.255 extracted from

  • Kumari, M.; Kozmon, S.; Kulhanek, P.; Stepan, J.; Tvaroska, I.; Koca, J.
    Exploring reaction pathways for O-GlcNAc transferase catalysis. A string method study (2015), J. Phys. Chem. B, 119, 4371-4381.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
hybrid quantum mechanics/molecular mechanics analysis of reaction paths using alpha-phosphate and Asp554 as the catalytic bases. The mechanism with alpha-phosphate acting as the base is favorable. The reaction has a rate-limiting free energy barrier of 23.5 kcal/mol, whereas reactions utilizing Asp554 and water-assisted alpha-phosphate have barriers of 41.7 and 40.9 kcal/mol, respectively Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
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