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Literature summary for 2.4.1.255 extracted from

  • Trapannone, R.; Mariappa, D.; Ferenbach, A.T.; van Aalten, D.M.
    Nucleocytoplasmic human O-GlcNAc transferase is sufficient for O-GlcNAcylation of mitochondrial proteins (2016), Biochem. J., 473, 1693-1702.
    View publication on PubMedView publication on EuropePMC
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Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion isoform 2 Homo sapiens 5739
-
nucleoplasm isoforms 3 and 4 Homo sapiens 5654
-

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HEK-293 cell
-
 Homo sapiens
-
HeLa cell
-
 Homo sapiens
-

General Information

General Information Comment Organism
physiological function endogenous mitochondrial isoform 2 of OGT is not detected in a range of human cell lines, experiments suggest the expression of only a single OGT isoform. Overexpression of the nucleocytoplasmic OGT isoform leads to increased O-GlcNAcylation of mitochondrial proteins, nucleocytoplasmic OGT is necessary and sufficient for the generation of the O-GlcNAc mitochondrial proteome Homo sapiens