Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
- |
Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C835A | the mutation has no effect compared with wild type enzyme | Homo sapiens |
C911A | active site mutant | Homo sapiens |
C917A | active site mutant | Homo sapiens |
K842A | active site mutant | Homo sapiens |
T914A | active site mutant | Homo sapiens |
T921A | active site mutant | Homo sapiens |
T922A | active site mutant | Homo sapiens |
Y841A | the mutation has no effect compared with wild type enzyme | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-methoxyphenyl 5-acetyl-3-hydroxy-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | the compound fully inactivates the enzyme within 5 min at a 1:1 ratio of inhibitor:enzyme | Homo sapiens | |
4-methoxyphenyl 6-chloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | about 30% inhibition with a 3fold excess of inhibitor | Homo sapiens | |
phenyl 3-hydroxy-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | about 70% inhibition with a 3fold excess of inhibitor | Homo sapiens | |
phenyl 3-hydroxy-5-methoxy-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | about 10% inhibition with a 3fold excess of inhibitor | Homo sapiens | |
phenyl 3-hydroxy-5-nitro-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | about 60% inhibition with a 3fold excess of inhibitor | Homo sapiens | |
phenyl 6-chloro-3-hydroxy-2-oxo-2,3-dihydro-1H-indole-1-carboxylate | the compound causes an irreversible loss of enzyme activity, about 48% inhibition with a 3fold excess of inhibitor | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-N-acetyl-D-glucosamine + KKKYPGGSTPVSSANMM | - |
Homo sapiens | UDP + ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
O-linked N-acetylglucosamine transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |