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Literature summary for 2.4.1.255 extracted from

  • Iwashita, Y.; Fukuchi, N.; Waki, M.; Hayashi, K.; Tahira, T.
    Genome-wide repression of NF-kappaB target genes by transcription factor MIBP1 and its modulation by O-linked beta-N-acetylglucosamine (O-GlcNAc) transferase (2012), J. Biol. Chem., 287, 9887-9900.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Escherichia coli and HEK-293 cells Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc + c-MYC intron binding protein 1
-
Homo sapiens UDP + N-acetyl-D-gluosaminyl-[c-MYC intron binding protein 1]
-
?

Subunits

Subunits Comment Organism
? x * about 110000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
Homo sapiens
O-linked beta-N-acetylglucosamine transferase
-
Homo sapiens
OGT
-
Homo sapiens

General Information

General Information Comment Organism
malfunction enzyme knockdown results in nuclear factor-kappaB reporter activation in the cells treated with 10 ng/ml tumor necrosis factor-alpha Homo sapiens
physiological function a post-translational modification enzyme that adds an O-linked beta-N-acetylglucosamine monosaccharide to serine or threonine residues of various proteins Homo sapiens