Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O15294 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
Hep-G2 cell | - |
Homo sapiens | - |
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-GlcNAc + PGC-1alpha | - |
Homo sapiens | UDP + N-acetyl-D-gluosaminyl-[PGC-1alpha] | - |
? |
Synonyms | Comment | Organism |
---|---|---|
O-GlcNAc transferase | - |
Homo sapiens |
OGT | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knockdown of O-GlcNAc transferase and host cell factor C1 decreases gluconeogenesis | Homo sapiens |
metabolism | host cell factor C1 recruits the enzyme to O-linked beta-N-acetylglucosaminate PGC-1alpha, and O-linked beta-N-acetylglucosamination facilitates the binding of the deubiquitinase BAP1, thus protecting PGC-1alpha from degradation and promoting gluconeogenesis | Homo sapiens |