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Literature summary for 2.4.1.255 extracted from

  • Ruan, H.B.; Han, X.; Li, M.D.; Singh, J.P.; Qian, K.; Azarhoush, S.; Zhao, L.; Bennett, A.M.; Samuel, V.T.; Wu, J.; Yates, J.R.; Yang, X.
    O-GlcNAc transferase/host cell factor C1 complex regulates gluconeogenesis by modulating PGC-1alpha stability (2012), Cell Metab., 16, 226-237.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Homo sapiens O15294
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc + PGC-1alpha
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Homo sapiens UDP + N-acetyl-D-gluosaminyl-[PGC-1alpha]
-
?

Synonyms

Synonyms Comment Organism
O-GlcNAc transferase
-
Homo sapiens
OGT
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Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown of O-GlcNAc transferase and host cell factor C1 decreases gluconeogenesis Homo sapiens
metabolism host cell factor C1 recruits the enzyme to O-linked beta-N-acetylglucosaminate PGC-1alpha, and O-linked beta-N-acetylglucosamination facilitates the binding of the deubiquitinase BAP1, thus protecting PGC-1alpha from degradation and promoting gluconeogenesis Homo sapiens