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Literature summary for 2.4.1.255 extracted from

  • Taylor, R.P.; Parker, G.J.; Hazel, M.W.; Soesanto, Y.; Fuller, W.; Yazzie, M.J.; McClain, D.A.
    Glucose deprivation stimulates O-GlcNAc modification of proteins through up-regulation of O-linked N-acetylglucosaminyltransferase (2008), J. Biol. Chem., 283, 6050-6057.
    View publication on PubMed
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Activating Compound

Activating Compound Comment Organism Structure
additional information beginning 12 h after treatment, glucose deprived human hepatocellular carcinoma (HepG2) cells demonstrate a 7.8fold increase in total O-GlcNAc modification compared with cells cultured in normal glucose (5 mM) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
O-(2-acetamido-2-deoxy-D-glucopyranosylidene) amino N-phenylcarbamate
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens regulation of O-GlcN acylation over a broad range of glucose concentrations, significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Hep-G2 cell human liver cell line Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information regulation of O-GlcN acylation over a broad range of glucose concentrations, significant induction of O-GlcNAc modification of a limited number of proteins under conditions of glucose deprivation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
O-linked N-acetylglucosaminyltransferase
-
 Homo sapiens
OGT
-
 Homo sapiens