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Literature summary for 2.4.1.255 extracted from

  • Golks, A.; Tran, T.T.; Goetschy, J.F.; Guerini, D.
    Requirement for O-linked N-acetylglucosaminyltransferase in lymphocytes activation (2007), EMBO J., 26, 4368-4379.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.255

Activating Compound

Activating Compound Comment Organism Structure
O-(2-acetamido-2-deoxy-D-glucopyranosylidene)amino N-phenylcarbamate inhibitor of O-GlcNAcase, increase of the level of O-GlcNAc modifications Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
cloning and expression of OGT in insect cells Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Homo sapiens 5829
-
nucleus
-
 Homo sapiens 5634
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
additional information dynamic modification of nuclear and cytoplasmic proteins with O-linked beta-N-acetylglucosamine Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
BJAB cell
-
 Homo sapiens
-
HEK-293 cell expression of OGT shows no significant influence on NFkappaB activity Homo sapiens
-
JURKAT cell
-
 Homo sapiens
-
lymphocyte
-
 Homo sapiens
-
PBMC cell line
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-GlcNAc + NFATc1
-
 Homo sapiens O-GlcNAc-NFATc1 + UDP
-
 ?
UDP-GlcNAc + Nup62 protein control substrate Homo sapiens UDP + N-acetyl-D-glucosmainyl-[Nup62 protein]
-
 ?
UDP-GlcNAc + transcription factor NFAT
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-[transcription factor NFAT]
-
 ?
UDP-GlcNAc + transcription factor NFkappaB
-
 Homo sapiens UDP + N-acetyl-D-glucosaminyl-[transcription factor NFkappaB]
-
 ?

Synonyms

Synonyms Comment Organism
N-acetylglucosaminyltransferase
-
 Homo sapiens
O-linked N-acetylglucosaminyltransferase
-
 Homo sapiens
OGT
-
 Homo sapiens
transferase OGT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
 assay at Homo sapiens

General Information

General Information Comment Organism
malfunction silencing of OGT results in impaired activation of T and B lymphocytes Homo sapiens
physiological function central factor for T- and B-lymphocytes activation. Overexpression of OGT and the use of inhibitors of the antagonistic enzyme O-GlcNAcase sensitizes T and B cells toward activation. SiRNAmediated knockdown of OGT in T cells leads to an impaired activation of the transcription factors NFAT and NFjB Homo sapiens