Literature summary for 2.4.1.250 extracted from

Liu, Y.B.; Chen, C.; Chaudhry, M.T.; Si, M.R.; Zhang, L.; Wang, Y.; Shen, X.H.
Enhancing Corynebacterium glutamicum robustness by over-expressing a gene, mshA, for mycothiol glycosyltransferase (2014), Biotechnol. Lett., 36, 1453-1459.

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Organism

Organism	UniProt	Comment	Textmining
Corynebacterium glutamicum	Q8NTA6	-	-
Corynebacterium glutamicum DSM 20300	Q8NTA6	-	-

General Information

General Information	Comment	Organism
physiological function	overexpression of the gene, MshA, coding for mycothiol glycosyl transferase improves the robustness of Corynebacterium glutamicum to various stresses. Intracellular mycothiol content is increased by 114% upon overexpression of MshA. Survival rates increased by 44, 39, 90, 77, 131, 87, 52, 47, 57, 85 and 33% as compared to wild-type under stress by H2O2 (40 mM), methylglyoxal (5.8 mM), erythromycin (0.08 mg/ml), streptomycin (0.005 mg/ml), Cd2+ (0.01 mM), Mn2+ (2 mM), formic acid (0.05%), acetic acid (0.15%), levulinic acid (0.25%), furfural (7.2 mM), and ethanol (10% v/v), respectively. Increased mycothiol content also decreases the concentration of reactive oxygen species in the presence of the above stresses	Corynebacterium glutamicum

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Release 2023.1 (January 2023)