Literature summary for 2.4.1.250 extracted from

Vilcheze, C.; Av-Gay, Y.; Attarian, R.; Liu, Z.; Hazbon, M.H.; Colangeli, R.; Chen, B.; Liu, W.; Alland, D.; Sacchettini, J.C.; Jacobs, W.R. Jr.
Mycothiol biosynthesis is essential for ethionamide susceptibility in Mycobacterium tuberculosis (2008), Mol. Microbiol., 69, 1316-1329.

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Organism

Organism	UniProt	Comment	Textmining
Mycobacterium tuberculosis	-	-	-

General Information

General Information	Comment	Organism
malfunction	seven independent missense or frameshift mutations within mshA are identified and characterized. Precise null deletion mutations of the mshA gene are generated by specialized transduction in three different strains of Mycobacterium tuberculosis. The mshA deletion mutants are defective in mycothiol biosynthesis, are only ethionamide-resistant and require catalase to grow. Biochemical studies suggest that the mechanism of ethionamide resistance in mshA mutants is likely due to a defect in ethionamide activation. In vivo, a mycothiol-deficient strain grows normally in immunodeficient mice, but is slightly defective for growth in immunocompetent mice. Mutations in mshA demonstrate the nonessentiality of mycothiol for growth in vitro and in vivo	Mycobacterium tuberculosis

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Release 2023.1 (January 2023)