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Literature summary for 2.4.1.226 extracted from

  • Gotoh, M.; Yada, T.; Sato, T.; Akashima, T.; Iwasaki, H.; Mochizuki, H.; Inaba, N.; Togayachi, A.; Kudo, T.; Watanabe, H.; Kimata, K.; Narimatsu, H.
    Molecular cloning and characterization of a novel chondroitin sulfate glucuronyltransferase that transfers glucuronic acid to N-acetylgalactosamine (2002), J. Biol. Chem., 277, 38179-38188.
    View publication on PubMed
Search for more literature for 2.4.1.226

Cloned(Commentary)

Cloned (Comment) Organism
enzyme domain containing beta-3-glycosyltransferase motifs, expressed in COS-7 cells ATCCCRL 1651 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0653
-
 chondroitin sulfate undecasaccharide
-
 Homo sapiens
0.0824
-
 UDP-glucuronic acid
-
 Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9P2E5 further cDNA: Kazusa DNA Research Institute number KIAA1402
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the glucuronic acid transfer rate roughly increases with increasing chain length Homo sapiens ?
-
 ?
additional information no substrates: chondroitin, chondroitin sulfate, dermatan sulfate, N-acetylheparosan, hyaluronan, heparan sulfate, heparin, hyaluronan heptasaccharides Homo sapiens ?
-
 ?
UDP-alpha-D-glucuronic acid + N-acetyl-D-galactosaminyl chondroitin polysaccharide polysaccharide substrate used after beta-glucuronidase treatment Homo sapiens UDP + beta-D-GlcA-(1->3)-beta-D-GalNAc-(1->4)-chondroitin polysaccharide
-
 ?
UDP-glucuronic acid + chondroitin heptasaccharide heptasaccharide having a N-acetylgalactosamine residue at its non-reducing terminus Homo sapiens ?
-
 ?
UDP-glucuronic acid + chondroitin sulfate heptasaccharide heptasaccharide having a N-acetylgalactosamine residue at its non-reducing terminus Homo sapiens ?
-
 ?
UDP-glucuronic acid + chondroitin sulfate undecasaccharide
-
 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 enzyme assay Homo sapiens