Cloned (Comment) | Organism |
---|---|
gene EXT1, creation of loxP-modified Ext1 allele and establishment of the Ext1 floxed mouse line (Ext1flox/flox), expression of the enzyme in Gdf-5-Cre transgenic mice, semiquantitative real-time PCR enzyme expression analysis | Mus musculus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | P97464 | gene EXT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
C3H10T1/2 cell | - |
Mus musculus | - |
mesenchymal cell | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
exostosin-1 | - |
Mus musculus |
EXT1 | - |
Mus musculus |
General Information | Comment | Organism |
---|---|---|
malfunction | ectopic cartilage forms in Ext1-deficient mouse embryo long bones, phenotype overview. perichondrium phenotype and border function regulation is deregulated in hereditary multiple exostoses. Ext1 deficiency stimulates cartilage formation | Mus musculus |
physiological function | perichondrium phenotype and border function are deranged by Ext1 and heparan sulfate in developing long bones, and in ectopic cartilage formation | Mus musculus |