Protein Variants | Comment | Organism |
---|---|---|
additional information | gene silencing by Rfng-specific siRNA and overexpression of Lfng or Mfng in asthmatic CD4+ T lymphocytes. Downregulation of Rfng and overexpression of Lfng or Mfng enhance Th1 cytokines but suppress Th2 cytokine production, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine | Rattus norvegicus | - |
[Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
three Fringe homologues Lfng, Mfng, and Rfng | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
T-lymphocyte | expression levels of three Fringe homologues in naive CD4+T cells in asthmatic rats, overview. Radical Fringe (Rfng) is highly expressed, whereas both Lunatic Fringe (Lfng) and Manic Fringe (Mfng) are expressed at low levels | Rattus norvegicus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
[Notch]-fucose + UDP-alpha-D-N-acetylglucosamine | - |
Rattus norvegicus | [Notch]-(3-O-beta-D-N-acetylglucosaminyl)fucose + UDP | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Fringe | - |
Rattus norvegicus |
LFNG | - |
Rattus norvegicus |
Lunatic Fringe | - |
Rattus norvegicus |
Manic fringe | - |
Rattus norvegicus |
MFng | - |
Rattus norvegicus |
O-fucose-beta1,3-N-acetylglucosaminyltransferase | - |
Rattus norvegicus |
Radical Fringe | - |
Rattus norvegicus |
Rfng | - |
Rattus norvegicus |
General Information | Comment | Organism |
---|---|---|
malfunction | Lfng overexpression results in significantly decreased Th2 cytokine production in asthma, which is the same effect as the gamma-secretase inhibitor GSI treatment alone, but has an increased effect on Th1 cytokines than GSI treatment | Rattus norvegicus |
physiological function | Fringe modulates Notch receptor expression and promotes the Notch signaling pathway through receptor-ligand binding, essential role of Fringe, overview. Notch signaling is more activated in asthmatic naive CD4+T cells than in control cells, and Lfng, but not Mfng or Rfng, partly inhibit Notch signaling in asthmatic naive CD4+T lymphocytes | Rattus norvegicus |