Literature summary for 2.4.1.222 extracted from

Correia, T.; Papayannopoulos, V.; Panin, V.; Woronoff, P.; Jiang, J.; Vogt, T.F.; Irvine, K.D.
Molecular genetic analysis of the glycosyltransferase Fringe in Drosophila (2003), Proc. Natl. Acad. Sci. USA, 100, 6404-6409.

Search for more literature for 2.4.1.222

Cloned(Commentary)

Cloned (Comment)	Organism
gene fng, DNA and amino acid sequence determination and analysis	Drosophila melanogaster

Protein Variants

Protein Variants	Comment	Organism
D327N	EMS mutagenesis, transheterozygote, mutation on allele 14, lethal phenotype	Drosophila melanogaster
E220K	EMS mutagenesis, transheterozygote, mutation on allele 3, lethal phenotype	Drosophila melanogaster
G295D	EMS mutagenesis, transheterozygote, mutation on allele L81, lethal phenotype	Drosophila melanogaster
K196E	EMS mutagenesis, transheterozygote, mutation on allele 11, lethal phenotype	Drosophila melanogaster
K196N	EMS mutagenesis, transheterozygote, mutation on allele 11, lethal phenotype	Drosophila melanogaster
L213F	EMS mutagenesis, transheterozygote, mutation on allele L83, lethal phenotype	Drosophila melanogaster
L398Q	EMS mutagenesis, transheterozygote, mutation on allele 2, phenotype overview	Drosophila melanogaster
additional information	construction and genetic analysis of mutated alleles, several mutants with introduced stop codons, mutant phenotypes analysis, mutants show altered wing vein numbers and structure, overview	Drosophila melanogaster
S350T	EMS mutagenesis, transheterozygote, mutation on allele 1, lethal phenotype	Drosophila melanogaster
T184M	EMS mutagenesis, transheterozygote, phenotype overview	Drosophila melanogaster

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
Notch + UDP-D-GlcNAc	Drosophila melanogaster	enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains	beta-D-glucosaminyl-Notch + UDP	-	?

Organism

Organism	UniProt	Comment	Textmining
Drosophila melanogaster	Q24324	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
Notch + UDP-D-GlcNAc	enzyme modulates signaling through Notch receptors by modifying O-linked fucose on epidermal growth factor-like domains	Drosophila melanogaster	beta-D-glucosaminyl-Notch + UDP	-	?
Notch + UDP-D-GlcNAc	Notch protein is O-fucosylated at a serine or threonine residue in the epidermal growth factor-like domain	Drosophila melanogaster	beta-D-glucosaminyl-Notch + UDP	-	?

Synonyms

Synonyms	Comment	Organism
beta1,3-N-acetylglucosaminyltransferase	-	Drosophila melanogaster
FNG	-	Drosophila melanogaster
Fringe protein	-	Drosophila melanogaster

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Release 2023.1 (January 2023)