Application | Comment | Organism |
---|---|---|
diagnostics | enzyme POFUT1 may serve as a diagnostic marker and a therapeutic target for oral squamous cell carcinoma cells | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
quantitative reverse transcriptase PCR enzyme expression analysis | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q9H488 | gene POFUT1 | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
epidermis | - |
Homo sapiens | - |
Ho-1-u-1 cell | - |
Homo sapiens | - |
HSC-2 cell | - |
Homo sapiens | - |
HSC-3 cell | - |
Homo sapiens | - |
HSC-4 cell | - |
Homo sapiens | - |
keratinocyte | - |
Homo sapiens | - |
KOSC2 cell | - |
Homo sapiens | - |
oral squamous cell carcinoma cell | oral squamous cell carcinoma cell-derived cell lines and primary oral squamous cell carcinoma cells, increased enzyme expression | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
Pofut1 | - |
Homo sapiens |
protein O-fucosyltransferase 1 | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | POFUT1 mRNA expression is upregulated in oral squamous cell carcinoma cells | up |
General Information | Comment | Organism |
---|---|---|
malfunction | cell proliferation of POFUT1 knockdown cells is significantly inhibited compared with that of control cells, phenotypes, overview | Homo sapiens |
physiological function | the enzyme adds O-fucose through O-glycosidic linkage to conserved serine or threonine residues in the epidermal growth factor-like repeats of a number of cellular surface and secreted proteins. ENzyme POFUT1 expression can contribute to cancer progression | Homo sapiens |