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Literature summary for 2.4.1.221 extracted from

  • Ma, L.; Dong, P.; Liu, L.; Gao, Q.; Duan, M.; Zhang, S.; Chen, S.; Xue, R.; Wang, X.
    Overexpression of protein O-fucosyltransferase 1 accelerates hepatocellular carcinoma progression via the Notch signaling pathway (2016), Biochem. Biophys. Res. Commun., 473, 503-510.
    View publication on PubMed
Search for more literature for 2.4.1.221

Application

Application Comment Organism
diagnostics Pofut1 overexpression clinically correlates with the unfavorable survival and high disease recurrence in hepatocellular carcinoma Homo sapiens
medicine an aberrant activated Pofut1-Notch pathway is involved in hepatocellular carcinoma progression, and blockage of this pathway can be a promising strategy for the therapy of hepatocellular carcinomas Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
quantitative real-time PCR enzyme expression analysis Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens Q9H488 gene POFUT1
-

Source Tissue

Source Tissue Comment Organism Textmining
HEP-3B cell
-
 Homo sapiens
-
Hep-G2 cell
-
 Homo sapiens
-
hepatocellular carcinoma cell analysis of enzyme expression in 8 HCC cell lines and 253 human HCC tissues, overview Homo sapiens
-
Huh7 cell
-
 Homo sapiens
-
MHCC-97L cell
-
 Homo sapiens
-
SMMC-7721 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
Pofut1
-
 Homo sapiens
protein O-fucosyltransferase 1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knockdown and overexpression of Pofut1 inhibits and accelerates the growth, migration and invasion of hepatocellular carcinoma cells, respectively Homo sapiens
physiological function the enzyme catalyzes the addition of O-linked fucose to the epidermal growth factor-like repeats of Notch. Pofut1 overexpression accelerates cell proliferation and migration in hepatocellular carcinoma cells and it promotes the binding of Notch ligand Dll1 to Notch receptor, and hence activates Notch signaling pathway in hepatocellular carcinoma cells Homo sapiens