Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | interleukin-12 i.e. IL-12, and TGF-beta1 strongly induce the enzyme in activated T-cells, IL-12 and TGF-beta1 are important for homing of the T-cells to inflammation sites in the skin and gut, respectively, via selectins, which are bound by ligands expressed by the T-cells involving the enzyme, induction by TGF-beta1 can be blocked by p38 mitogen-activated protein kinase, but is unaffected by mitogen-activated protein/extracellular signal-related kinase kinase inhibitor, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | the enzyme is essential for biosynthesis of selectin binding ligands in T-cells | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
endothelium | - |
Homo sapiens | - |
gut | - |
Homo sapiens | - |
leukocyte | buffy coat | Homo sapiens | - |
additional information | IL-12 and TGF-beta1 are important for homing of the T-cells to inflammation sites in the skin and gut, respectively, via selectins, which are bound by ligands expressed by the T-cells involving the enzyme | Homo sapiens | - |
peripheral blood mononuclear cell | CD4+ cell | Homo sapiens | - |
skin | - |
Homo sapiens | - |
T-lymphocyte | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
- |
Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | the enzyme is essential for biosynthesis of selectin binding ligands in T-cells | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alpha(1,3)-fucosyltransferase VII | - |
Homo sapiens |
FucT-VII | - |
Homo sapiens |