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Literature summary for 2.4.1.214 extracted from

  • Smithson, G.; Rogers, C.E.; Smith, P.L.; Scheidegger, E.P.; Petryniak, B.; Myers, J.T.; Kim, D.S.L.; Homeister, J.W.; Lowe, J.B.
    Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T cell trafficking to lymph nodes (2001), J. Exp. Med., 194, 601-614.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
additional information enzyme-deficient FucTVII-/- mice show contact hypersensitivity CHS deficiency resulting in strong or nearly complete deficiency in the complement of naive T-lymphocytes in lymph nodes for antigen-dependent activation, expansion, differentiation, and dissemination, enzyme deficiency also leads to deletion of E- and P-selectin ligands expression by Th1 and T cytotoxic 1 lymphocytes, and to annulation of T-cell trafficking Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
additional information T-cell content in wild-type and enzyme-deficient mice, overview Mus musculus
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T-cell
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Fuc-TVII is required for T helper 1 and T cytotoxic 1 lymphocyte selectin ligand expression and recruitment in inflammation, and together with Fuc-TIV regulates naive T-cell trafficking to lymph nodes Mus musculus ?
-
?

Synonyms

Synonyms Comment Organism
alpha(1,3)fucosyltransferase
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Mus musculus
Fuc-TVII
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Mus musculus