BRENDA - Reference to 2.4.1.212; Id = 736145

medicine

the role of HAS1 as a poor predictor in breast cancer, and is correlated with high relapse rate and short overall survival

Homo sapiens

gene HAS1, in addition to the full-length form, HAS1 has multiple transcript variants resulting from alternative splicing

Homo sapiens

additional information

both COS-1 and MCF-7 cell lines have negligible endogenous hyaluronan production, and even overexpression of HAS1 enzymes does not cause prominent changes in it. Upon treatment with glucose or glucosamine, compounds that increase the amounts of hyaluronan substrates, the HAS1 enzyme is able to produce significant amounts of hyaluronan

Homo sapiens

additional information

-

additional information

availability of substrate UDP-GlcNAc does not considerably influence the Km of Has1 toward UDP-GlcUA, whereas levels of UDP-GlcUA have a significant effect of the Km toward UDP-GlcNAc

Homo sapiens

cytoplasm

-

Homo sapiens

5737

-

cytoskeleton

-

Homo sapiens

5856

-

endoplasmic reticulum

-

Homo sapiens

5783

-

Golgi apparatus

-

Homo sapiens

5794

-

membrane

are integral membrane proteins with transmembrane domains in addition to membrane-associated domains

Homo sapiens

16020

-

microtubule

-

Homo sapiens

5874

-

additional information

the intracellular distribution pattern of HAS1 is distinct from other isoenzymes. In all cell types studied so far, a high proportion of HAS1 is accumulated intracellularly, with a faint signal detected on the plasma membrane and its protrusions. The recombinant GFP-HAS1 signal is mainly cytoplasmic, rather than on the plasma membrane, being distributed either diffusely or in cytoplasmic patches, and partially co-localizing with the Golgi apparatus. Transfected HAS1V-GFP constructs localize with cytoskeletal structures like microtubules

Homo sapiens

-

Mg2+

the enzyme requires Mg2+ or Mn2+ for activity

Homo sapiens

Mn2+

the enzyme requires Mg2+ or Mn2+ for activity

Homo sapiens

Q92839

gene HAS1

-

breast cancer cell

-

Homo sapiens

-

fibroblast

-

Homo sapiens

-

MCF-7 cell

-

Homo sapiens

-

mesothelioma cell

-

Homo sapiens

-

additional information

both full length and splice variants of HAS1 are expressed in malignancies like bladder and prostate cancers, multiple myeloma, and malignant mesothelioma

Homo sapiens

-

myeloma cell

-

Homo sapiens

-

prostate cancer cell

-

Homo sapiens

-

synoviocyte

-

Homo sapiens

-

urinary bladder cancer cell

-

Homo sapiens

-

UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

-

736145

Homo sapiens

UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

-

?

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]

-

736145

Homo sapiens

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]

-

?

HAS1

-

Homo sapiens

hyaluronan synthase 1

-

Homo sapiens

medicine

the role of HAS1 as a poor predictor in breast cancer, and is correlated with high relapse rate and short overall survival

Homo sapiens

gene HAS1, in addition to the full-length form, HAS1 has multiple transcript variants resulting from alternative splicing

Homo sapiens

additional information

both COS-1 and MCF-7 cell lines have negligible endogenous hyaluronan production, and even overexpression of HAS1 enzymes does not cause prominent changes in it. Upon treatment with glucose or glucosamine, compounds that increase the amounts of hyaluronan substrates, the HAS1 enzyme is able to produce significant amounts of hyaluronan

Homo sapiens

additional information

-

additional information

availability of substrate UDP-GlcNAc does not considerably influence the Km of Has1 toward UDP-GlcUA, whereas levels of UDP-GlcUA have a significant effect of the Km toward UDP-GlcNAc

Homo sapiens

cytoplasm

-

Homo sapiens

5737

-

cytoskeleton

-

Homo sapiens

5856

-

endoplasmic reticulum

-

Homo sapiens

5783

-

Golgi apparatus

-

Homo sapiens

5794

-

membrane

are integral membrane proteins with transmembrane domains in addition to membrane-associated domains

Homo sapiens

16020

-

microtubule

-

Homo sapiens

5874

-

additional information

the intracellular distribution pattern of HAS1 is distinct from other isoenzymes. In all cell types studied so far, a high proportion of HAS1 is accumulated intracellularly, with a faint signal detected on the plasma membrane and its protrusions. The recombinant GFP-HAS1 signal is mainly cytoplasmic, rather than on the plasma membrane, being distributed either diffusely or in cytoplasmic patches, and partially co-localizing with the Golgi apparatus. Transfected HAS1V-GFP constructs localize with cytoskeletal structures like microtubules

Homo sapiens

-

Mg2+

the enzyme requires Mg2+ or Mn2+ for activity

Homo sapiens

Mn2+

the enzyme requires Mg2+ or Mn2+ for activity

Homo sapiens

breast cancer cell

-

Homo sapiens

-

fibroblast

-

Homo sapiens

-

MCF-7 cell

-

Homo sapiens

-

mesothelioma cell

-

Homo sapiens

-

additional information

both full length and splice variants of HAS1 are expressed in malignancies like bladder and prostate cancers, multiple myeloma, and malignant mesothelioma

Homo sapiens

-

myeloma cell

-

Homo sapiens

-

prostate cancer cell

-

Homo sapiens

-

synoviocyte

-

Homo sapiens

-

urinary bladder cancer cell

-

Homo sapiens

-

UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

-

736145

Homo sapiens

UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-[nascent hyaluronan]

-

?

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]

-

736145

Homo sapiens

UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-[nascent hyaluronan]

-

?

Homo sapiens

the enzyme expression is decreased in transcriptional regulation by estradiol, 4-methylumbelliferone, and TGF-beta1

down

Homo sapiens

Has1 is upregulated in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease. The enzyme expression is increased in transcriptional regulation by factors EGF, FGF2, FGF, forskolin, IGF, IL-1beta, PDGF, progesterone, prostaglandin D2, prostaglandin E2, and TGF-beta

up

additional information

An important factor affecting activity of all HAS enzymes is the cytoplasmic availability of substrates, namely, UDP-GlcUA and UDP-GlcNAc. This role of substrates is particularly interesting in regulation of HAS1 as its activity of hyaluronan production in many cell models is low or absent unless stimulated

Homo sapiens

physiological function

hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. The role of HAS1 in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity. Isozyme Has1 is upregulated in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease. Both full length and splice variants of HAS1 are expressed in malignancies like bladder and prostate cancers, multiple myeloma, and malignant mesothelioma. The pericellular hyaluronan coat produced by HAS1 is usually thin without induction by inflammatory agents or glycemic stress and depends on CD44–HA interactions. These specific interactions regulate the organization of hyaluronan into a leukocyte recruiting matrix during inflammatory responses. Despite the apparently minor enzymatic activity of HAS1 under normal conditions, it may be an important factor under conditions associated with glycemic stress like metabolic syndrome, inflammation, and cancer. HAS1 expression is transcriptionally regulated by transforming growth factor-beta in synoviocytes and by the pro-inflammatory cytokine interleukin-1beta in fibroblasts, while these factors may have similar or opposite effects on other HASs, depending on the cell type. Has1 is associated with breast tumor and with estrogen receptor negativity, HER2 positivity, high relapse rate, and short overall survival

Homo sapiens

additional information

An important factor affecting activity of all HAS enzymes is the cytoplasmic availability of substrates, namely, UDP-GlcUA and UDP-GlcNAc. This role of substrates is particularly interesting in regulation of HAS1 as its activity of hyaluronan production in many cell models is low or absent unless stimulated

Homo sapiens

physiological function

hyaluronan synthase 1 (HAS1) is one of three isoenzymes responsible for cellular hyaluronan synthesis. The role of HAS1 in hyaluronan production seems to be insignificant compared to the two other isoenzymes, HAS2 and HAS3, which have higher enzymatic activity. Isozyme Has1 is upregulated in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease. Both full length and splice variants of HAS1 are expressed in malignancies like bladder and prostate cancers, multiple myeloma, and malignant mesothelioma. The pericellular hyaluronan coat produced by HAS1 is usually thin without induction by inflammatory agents or glycemic stress and depends on CD44–HA interactions. These specific interactions regulate the organization of hyaluronan into a leukocyte recruiting matrix during inflammatory responses. Despite the apparently minor enzymatic activity of HAS1 under normal conditions, it may be an important factor under conditions associated with glycemic stress like metabolic syndrome, inflammation, and cancer. HAS1 expression is transcriptionally regulated by transforming growth factor-beta in synoviocytes and by the pro-inflammatory cytokine interleukin-1beta in fibroblasts, while these factors may have similar or opposite effects on other HASs, depending on the cell type. Has1 is associated with breast tumor and with estrogen receptor negativity, HER2 positivity, high relapse rate, and short overall survival

Homo sapiens

the enzyme expression is decreased in transcriptional regulation by estradiol, 4-methylumbelliferone, and TGF-beta1

down

Homo sapiens

Has1 is upregulated in states associated with inflammation, like atherosclerosis, osteoarthritis, and infectious lung disease. The enzyme expression is increased in transcriptional regulation by factors EGF, FGF2, FGF, forskolin, IGF, IL-1beta, PDGF, progesterone, prostaglandin D2, prostaglandin E2, and TGF-beta

up

756468

Eisele

-

In vitro one-pot enzymatic sy ...

Pasteurella multocida

ChemCatChem

10

2969-2981

2018

-

1

-

1

2

-

3

-

1

-

1

-

2

-

1

-

2

-

1

-

2

-

3

-

1

-

2

-

2

-

735574

Pure

Role for hyaluronan synthase 3 ...

Homo sapiens, Mus musculus, Mus musculus C57/BL6J

Arterioscler. Thromb. Vasc. Biol.

36

224-225

2016

-

62

-

5

-

6

-

736725

Li

Hyaluronan synthase 2 regulate ...

Mus musculus

Matrix Biol.

55

35-48

2016

-

1

-

1

-

3

-

4

-

2

-

1

-

1

-

4

-

1

2

1

-

737218

Chavoshinejad

Localisation and endocrine con ...

Ovis aries

Reprod. Fertil. Dev.

28

765-775

2016

-

3

-

6

-

10

-

8

-

3

-

10

-

3

-

3

-

736067

Takabe

Hyaluronan synthase 3 (HAS3) o ...

Homo sapiens

Exp. Cell Res.

337

1-15

2015

-

1

-

1

-

2

-

3

-

1

-

2

-

1

-

1

-

2

-

1

-

1

2

1

-

736145

Siiskonen

Hyaluronan synthase 1: a myste ...

Homo sapiens

Front. Immunol.

6

43

2015

-

1

-

1

-

1

7

2

-

1

-

9

-

2

-

2

-

1

-

1

-

1

7

2

-

9

-

2

-

2

-

737217

Garoby-Salom

Hyaluronan synthase-2 upregula ...

Mus musculus, Mus musculus 129/Sv

Redox Biol.

4

118-126

2015

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

1

-

736064

Siiskonen

Hyaluronan synthase 1 (HAS1) p ...

Homo sapiens

Exp. Cell Res.

320

153-163

2014

-

1

-

1

-

2

-

4

-

3

-

6

-

2

-

1

-

1

-

2

-

4

-

6

-

1

-

736219

Toerroenen

Tissue distribution and subcel ...

Mus musculus

Histochem. Cell Biol.

141

17-31

2014

-

3

-

9

-

4

-

27

-

3

-

3

-

9

-

27

-

6

-

736643

Kooy

-

Kinetic and structural analysi ...

Pasteurella multocida

J. Mol. Catal. B

102

138-145

2014

-

1

-

1

5

-

1

-

3

-

1

-

1

2

-

8

-

1

-

4

1

-

1

-

1

-

5

-

1

-

3

-

1

-

8

-

1

-

4

1

-

736724

Vigetti

Metabolic control of hyalurona ...

Mammalia, Streptococcus sp., Pasteurella multocida

Matrix Biol.

35

8-13

2014

3

-

2

-

6

-

3

-

2

-

8

3

2

-

3

-

2

-

6

-

2

-

8

3

-

4

-

721994

Caskey

Lentiviral-mediated over-expre ...

Mus musculus, Mus musculus C57BL/6

Cell Tissue Res.

351

117-125

2013

-

1

-

142

-

1

-

2

-

1

-

1

-

2

-

722816

Rilla

Hyaluronan synthase 1 (HAS1) r ...

Homo sapiens

J. Biol. Chem.

288

5973-5983

2013

-

3

-

3

-

2

-

3

-

9

-

8

-

6

-

12

-

4

3

-

3

-

3

-

3

-

6

-

3

-

9

-

6

-

12

-

3

-

3

-

4

-

721931

Medina

Hyaluronan synthase mediates d ...

Streptococcus dysgalactiae subsp. equisimilis

BMC Biochem.

13

2-2

2012

-

3

-

2

-

1

-

8

-

1

-

3

-

2

-

1

-

1

-

1

-

722359

Weigel

Hyaluronan synthase polymerizi ...

Streptococcus dysgalactiae subsp. equisimilis

Glycobiology

22

1302-1310

2012

-

14

-

1

-

1

-

4

-

19

-

2

1

-

1

-

14

-

1

-

1

-

19

-

1

-

1

-

1

-

722782

Vigetti

Role of UDP-N-acetylglucosamin ...

Homo sapiens

J. Biol. Chem.

287

35544-35555

2012

2

-

1

-

1

-

2

1

-

3

-

2

-

1

-

1

-

3

-

2

-

2

-

1

-

1

-

2

1

-

3

-

1

-

1

-

3

-

2

-

722986

Hubbard

The hyaluronan synthase cataly ...

Streptococcus dysgalactiae subsp. equisimilis

J. Mol. Biol.

418

21-31

2012

-

1

-

1

-

1

-

7

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

722741

Vigetti

Hyaluronan synthesis is inhibi ...

Homo sapiens

J. Biol. Chem.

286

7917-7924

2011

-

1

-

1

-

4

-

2

1

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

4

-

2

1

-

1

-

1

-

1

-

2

-

721933

Nykopp

Hyaluronan synthases (HAS1-3) ...

Homo sapiens

BMC Cancer

10

512

2010

-

1

-

2

-

4

-

1

-

4

-

722678

Karousou

The activity of hyaluronan syn ...

Mus musculus

J. Biol. Chem.

285

23647-23654

2010

-

1

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

1

-

698529

Sheng

Use of induction promoters to ...

Streptococcus equi subsp. zooepidemicus

J. Appl. Microbiol.

107

136-144

2009

-

1

-

1

-

9

-

1

-

1

-

701980

David-Raoudi

Chondroitin sulfate increases ...

Homo sapiens

Arthritis Rheum.

60

760-770

2009

-

6

-

5

-

1

-

5

-

3

-

3

-

702420

Berdiaki

bFGF induces changes in hyalur ...

Homo sapiens

Biochim. Biophys. Acta

1790

1258-1265

2009

-

1

-

1

-

1

-

1

-

702525

Miyake

Expression of hyaluronan synth ...

Sus scrofa

Biol. Reprod.

80

249-257

2009

-

4

-

6

-

6

-

1

-

702883

Nykopp

Expression of hyaluronan synth ...

Homo sapiens

BMC Cancer

9

143

2009

-

2

-

2

-

4

-

2

-

2

-

4

-

702937

Campo

Effect of cytokines on hyaluro ...

Homo sapiens

Br. J. Biomed. Sci.

66

28-36

2009

-

3

-

3

-

3

-

4

-

4

-

703583

Kultti

4-Methylumbelliferone inhibits ...

Homo sapiens

Exp. Cell Res.

315

1914-1923

2009

-

3

-

10

-

1

-

10

-

2

-

704501

Makkonen

Regulation of the hyaluronan s ...

Homo sapiens

J. Biol. Chem.

284

18270-18281

2009

-

3

-

1

-

1

-

704503

Ghosh

Aberrant splice variants of HA ...

Homo sapiens

J. Biol. Chem.

284

18840-18850

2009

-

1

-

3

-

1

-

1

-

1

-

1

-

1

-

704558

Vigetti

Modulation of hyaluronan synth ...

Homo sapiens

J. Biol. Chem.

284

30684-30694

2009

4

1

-

1

-

2

-

2

-

2

-

2

-

1

-

4

1

-

1

-

2

-

2

-

2

-

1

-

705486

Ruegheimer

Hyaluronan synthases and hyalu ...

Rattus norvegicus

Matrix Biol.

28

390-395

2009

-

2

-

6

-

2

-

2

-

2

-

1

-

1

-

706795

Dunn

Inhibition of hyaluronan synth ...

Homo sapiens

Surgery

145

322-329

2009

-

2

-

2

-

2

-

2

-

690619

Kakizaki

Up-regulation of hyaluronan sy ...

Homo sapiens

Arch. Biochem. Biophys.

471

85-93

2008

2

-

1

-

2

-

6

-

3

-

2

-

4

-

2

-

1

-

2

-

3

-

2

-

691192

Allison

Endogenous overexpression of h ...

Rattus norvegicus

Biomaterials

29

2969-2976

2008

-

1

-

2

-

3

-

1

-

2

-

2

-

1

-

2

-

1

-

2

-

693068

Stuhlmeier

Hyaluronan production in synov ...

Homo sapiens

J. Biol. Chem.

283

16781-16789

2008

5

-

2

-

1

-

2

-

2

-

2

-

5

-

2

-

2

-

2

-

702854

Adamia

Inherited and acquired variati ...

Homo sapiens

Blood

112

5111-5121

2008

-

1

-

4

-

4

-

1

-

1

-

4

-

671308

Krupa

Quantitative continuous assay ...

Pasteurella multocida

Anal. Biochem.

361

218-225

2007

-

1

-

1

-

3

1

-

4

-

1

-

1

-

2

-

1

-

1

-

1

-

3

1

-

1

-

1

-

2

-

672412

Pummill

The functional molecular mass ...

Pasteurella multocida

Biochim. Biophys. Acta

1770

286-290

2007

-

1

-

14

-

1

-

1

-

1

-

673417

Jong

Identification and characteriz ...

Cryptococcus neoformans

Eukaryot. Cell

6

1486-1496

2007

-

1

-

1

-

17

-

1

-

1

-

1

-

1

-

1

-

674872

Tracy

Acceptor specificity of the Pa ...

Pasteurella multocida

J. Biol. Chem.

282

337-344

2007

-

1

-

11

-

6

-

1

-

1

-

6

-

690402

Kyossev

An enzyme capture assay for an ...

Homo sapiens, Streptococcus dysgalactiae subsp. equisimilis

Anal. Biochem.

371

62-70

2007

-

2

-

4

-

8

-

1

-

4

-

7

6

-

2

-

2

-

4

-

1

-

4

-

6

-

2

-

690807

Li

Growth factor regulation of hy ...

Homo sapiens, Mus musculus

Biochem. J.

404

327-336

2007

2

-

2

-

2

-

4

-

2

-

8

-

4

-

4

-

2

-

2

-

2

-

4

-

8

-

4

-

691021

Campo

Differential effect of growth ...

Homo sapiens

Biochemistry

72

974-982

2007

3

-

2

-

4

-

2

-

2

-

2

-

3

-

2

-

2

-

2

-

691042

Stuhlmeier

Prostaglandin E2: A potent act ...

Homo sapiens

Biochim. Biophys. Acta

1770

121-129

2007

5

-

1

-

2

-

1

-

1

-

2

-

2

-

5

-

1

-

2

-

1

-

2

-

691191

Allison

The effect of endogenous overe ...

Rattus norvegicus

Biomaterials

28

5509-5517

2007

-

1

-

1

-

2

-

1

-

1

-

2

-

1

-

1

-

1

-

2

-

1

-

2

-

691451

Mao

Recombinant synthesis of hyalu ...

Pasteurella multocida

Biotechnol. Prog.

23

1038-1042

2007

-

1

-

2

-

15

-

1

-

2

-

3

-

1

-

2

-

1

-

2

-

691893

Bartolo

The distribution of renal hyal ...

Notomys alexis

Comp. Biochem. Physiol. A

148

853-860

2007

-

3

-

3

-

6

-

11

-

5

-

6

-

9

-

3

-

3

-

6

-

5

-

6

-

692221

Nishitsuka

Hyaluronan production regulati ...

Sus scrofa

Exp. Eye Res.

85

539-545

2007

2

-

1

-

2

-

3

-

2

-

2

-

2

-

2

-

1

-

2

-

2

-

2

-

692996

Bourguignon

Heregulin-mediated ErbB2-ERK s ...

Homo sapiens

J. Biol. Chem.

282

19426-19441

2007

3

1

-

3

-

3

6

-

6

-

3

-

9

48

-

6

-

6

-

3

1

-

9

-

3

6

-

3

-

9

48

-

6

-

692998

Bharadwaj

Inducible hyaluronan productio ...

Homo sapiens

J. Biol. Chem.

282

20561-20572

2007

-

1

-

2

-

3

-

2

-

2

-

2

-

1

-

2

-

2

-

2

-

693001

Meran

Involvement of hyaluronan in r ...

Homo sapiens

J. Biol. Chem.

282

25687-25697

2007

2

-

1

-

1

-

2

-

2

-

1

-

2

-

2

-

2

-

1

-

1

-

2

-

1

-

2

-

693368

Carulli

Upregulation of aggrecan, link ...

Rattus norvegicus

J. Comp. Neurol.

501

83-94

2007

-

1

-

2

-

6

-

8

-

2

-

4

-

1

-

2

-

8

-

2

-

693592

Sim

Black rice (Oryza sativa L. va ...

Homo sapiens

J. Microbiol. Biotechnol.

17

271-279

2007

1

-

1

-

2

-

4

-

3

-

2

-

2

-

1

-

1

-

2

-

3

-

2

-

695183

Fischer

Regulation of hyaluronan synth ...

Mammalia

Thromb. Haemost.

98

287-295

2007

8

-

1

-

2

-

1

-

2

-

1

-

9

-

2

-

2

-

8

-

1

-

2

-

1

-

2

-

9

-

2

-

671862

Goentzel

Recombinant human hyaluronan s ...

Homo sapiens

Biochem. J.

396

347-354

2006

-

1

-

1

-

3

-

1

-

2

-

1

-

1

-

1

-

674085

Nikitovic

Transforming growth factor-bet ...

Homo sapiens

IUBMB Life

58

47-53

2006

-

2

-

2

-

3

-

2

-

674537

Kumari

Mutation of two intramembrane ...

Streptococcus dysgalactiae subsp. equisimilis

J. Biol. Chem.

281

11755-11760

2006

-

1

-

6

-

1

-

6

-

1

-

1

-

6

-

1

-

674706

Weigel

Phospholipid dependence and li ...

Streptococcus dysgalactiae subsp. equisimilis

J. Biol. Chem.

281

36542-36551

2006

3

-

1

-

4

-

1

-

1

-

3

-

1

-

1

-

675030

Wilkinson

Overexpression of hyaluronan s ...

Mus musculus

J. Cell. Physiol.

206

378-385

2006

-

1

-

1

-

4

-

1

-

1

-

1

-

1

-

675765

Adams

Expression of hyaluronan synth ...

Homo sapiens

Matrix Biol.

25

40-46

2006

-

2

-

2

-

2

-

2

-

657784

Uchiyama

Regulation of hyaluronan synth ...

Mus musculus

Biochem. Biophys. Res. Commun.

327

927-932

2005

1

-

1

-

1

-

7

-

8

-

1

-

1

-

1

-

1

-

1

-

8

-

1

-

658855

Kumari

Identification of a membrane-l ...

Streptococcus dysgalactiae subsp. equisimilis

Glycobiology

15

529-539

2005

-

1

-

15

-

2

-

1

-

1

-

6

-

1

-

2

1

2

1

-

1

-

1

-

15

-

2

-

1

-

1

-

1

-

2

1

-

1

-

659455

Tlapak-Simmons

Hyaluronan biosynthesis by cla ...

Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes

J. Biol. Chem.

280

13012-13018

2005

-

1

-

2

-

2

-

13

-

1

2

-

6

-

4

2

-

2

-

1

-

2

-

2

-

1

-

6

-

2

-

2

-

659492

Rilla

Plasma membrane residence of h ...

Mus musculus

J. Biol. Chem.

280

31890-31897

2005

-

1

-

2

-

1

-

5

-

2

-

1

-

1

-

2

-

1

-

5

-

672775

Adamia

Intronic splicing of hyalurona ...

Homo sapiens

Blood

105

4836-4844

2005

-

1

-

6

-

2

-

2

-

1

-

2

-

673244

Tien

Three vertebrate hyaluronan sy ...

Mus musculus

Dev. Dyn.

233

130-141

2005

-

8

-

3

-

3

-

3

-

673466

Nishida

Antisense inhibition of hyalur ...

Homo sapiens

Exp. Cell Res.

307

194-203

2005

-

4

-

3

-

1

-

3

-

658093

Tlapak-Simmons

Characterization of the purifi ...

Streptococcus dysgalactiae subsp. equisimilis

Biochemistry

43

9234-9242

2004

2

-

1

-

1

14

1

3

1

-

4

-

1

-

3

1

-

1

2

-

4

-

2

-

1

-

1

-

14

4

1

3

1

-

1

-

3

1

-

1

2

-

659334

Itano

Selective expression and funct ...

Rattus norvegicus

J. Biol. Chem.

279

18679-18687

2004

-

2

-

2

-

5

-

6

-

9

3

-

8

-

3

-

3

-

2

-

2

-

5

-

9

3

-

8

-

3

-

3

-

659346

Hoshi

An engineered hyaluronan synth ...

Homo sapiens

J. Biol. Chem.

279

2341-2349

2004

-

2

1

-

1

-

1

-

7

-

2

-

1

-

1

-

2

1

-

1

-

1

-

2

-

1

-

1

-

658841

Jing

Analysis of the two active sit ...

Pasteurella multocida, Pasteurella multocida type A

Glycobiology

13

661-671

2003

-

1

-

19

-

1

-

4

-

2

-

5

-

1

-

6

-

2

1

-

1

-

19

-

1

-

4

-

2

-

6

-

1

-

395260

Sayo

Hyaluronan synthase 3 regulate ...

Homo sapiens

J. Invest. Dermatol.

118

43-48

2002

-

1

-

5

-

2

-

1

-

1

-

2

-

1

-

658945

Itano

Mammalian hyaluronan synthases ...

Homo sapiens, Mus musculus

IUBMB Life

54

195-199

2002

-

2

-

1

-

2

-

2

-

2

-

2

-

4

2

4

-

2

-

1

-

2

-

2

-

2

-

4

2

-

658946

Weigel

Functional characteristics and ...

Pasteurella multocida, Streptococcus pyogenes

IUBMB Life

54

201-211

2002

1

-

2

-

2

1

2

-

9

-

1

2

-

7

3

4

-

1

-

2

-

2

1

2

-

1

-

7

3

-

659171

Kumari

The streptococcal hyaluronan s ...

Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes

J. Biol. Chem.

277

13943-13951

2002

-

1

-

16

-

12

25

2

-

2

-

9

-

1

-

1

-

6

-

4

1

-

1

-

1

-

16

-

12

-

25

2

-

2

-

1

-

1

-

6

-

1

-

1

-

659175

Pummill

Evaluation of critical structu ...

Xenopus laevis

J. Biol. Chem.

277

21610-21616

2002

-

1

-

14

-

2

18

-

1

-

4

-

1

-

2

-

2

1

-

1

-

1

-

14

-

2

-

18

-

1

-

2

-

1

-

1

-

395257

Heldermon

Site-directed mutation of cons ...

Streptococcus pyogenes

Glycobiology

11

1017-1024

2001

-

1

-

1

-

1

-

1

-

1

-

12

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

395256

Jing

Dissection of the two transfer ...

Pasteurella multocida

Glycobiology

10

883-889

2000

-

1

-

2

-

2

-

1

-

6

-

1

-

1

-

2

-

2

-

1

-

1

-

395251

Itano

Three isoforms of mammalian hy ...

Mus musculus

J. Biol. Chem.

274

25085-25092

1999

-

1

-

7

1

-

1

-

3

-

1

-

1

-

7

1

-

1

-

1

-

395253

Tlapak-Simmons

Purification and lipid depende ...

Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes

J. Biol. Chem.

274

4239-4245

1999

-

2

-

4

1

-

2

-

20

-

2

-

2

-

4

1

-

2

-

2

-

395254

DeAngelis

Molecular directionality of po ...

Pasteurella multocida

J. Biol. Chem.

274

26557-26562

1999

-

1

-

1

-

1

-

17

-

1

-

1

-

1

-

1

-

1

-

395252

Pummill

Enzymological characterization ...

Xenopus laevis, Xenopus laevis protein DG42

J. Biol. Chem.

273

4976-4981

1998

-

1

-

2

-

1

-

2

-

7

-

2

-

1

-

1

-

2

-

1

-

2

-

2

-

1

-

395258

Asplund

Characterization of hyaluronan ...

Homo sapiens

Biochim. Biophys. Acta

1380

377-388

1998

-

1

-

1

-

6

-

1

-

5

-

1

-

1

-

1

-

1

-

5

-

1

-

395249

Kumari

Molecular cloning, expression, ...

Streptococcus dysgalactiae subsp. equisimilis

J. Biol. Chem.

272

32539-32546

1997

-

1

-

2

1

-

31

-

1

-

1

-

2

1

-

1

-

395250

DeAngelis

Hyaluronan synthase of chlorel ...

Paramecium bursaria Chlorella virus 1

Science

278

1800-1803

1997

-

1

-

3

-

1

-

16

-

1

-

1

-

1

-

3

-

1

-

1

-

1

-

395248

Spicer

Molecular cloning and characte ...

Mus musculus

J. Biol. Chem.

271

23400-23406

1996

-

1

-

1

-

16

-

1

-

1

-

1

-

1

-

395247

DeAngelis

Immunochemical confirmation of ...

Streptococcus pyogenes

Biochemistry

33

9033-9039

1994

-

1

-

1

-

1

-

12

-

1

-

1

-

1

-

1

-

1

-

395259

Klewes

Intracellular signal transduct ...

Mus musculus

J. Cell. Physiol.

160

539-544

1994

-

1

-

1

-

1

-

1

-

1

-

1

-

1

-

395246

DeAngelis

Molecular cloning, identificat ...

Streptococcus pyogenes

J. Biol. Chem.

268

19181-19184

1993

-

1

-

1

-

1

-

18

-

1

-

1

-

1

-

1

-

1

-

Hyaluronan synthase 1: a mysterious enzyme with unexpected functions

Data extracted from this reference: