Literature summary for 2.4.1.212 extracted from

Dunn, K.M.; Lee, P.K.; Wilson, C.M.; Iida, J.; Wasiluk, K.R.; Hugger, M.; McCarthy, J.B.
Inhibition of hyaluronan synthases decreases matrix metalloproteinase-7 (MMP-7) expression and activity (2009), Surgery, 145, 322-329.

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Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	O00219	isoform HAS3	-
Homo sapiens	Q92819	isoform HAS2	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
SW-620 cell	-	Homo sapiens	-

General Information

General Information	Comment	Organism
physiological function	inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 20%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression	Homo sapiens
physiological function	inhibition of HAS2 expression by siRNA decreases matrix metalloprotein MMP-7 expression by about 30%, and dramaticlly decreases MMP-7 protein, and enzymatic activity. HAS isoforms and hyaluronan may mediate cellular invasion via changes in matrix metalloprotein MMP-7 expression	Homo sapiens

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Release 2023.1 (January 2023)