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Literature summary for 2.4.1.212 extracted from

  • Tlapak-Simmons, V.L.; Baggenstoss, B.A.; Clyne, T.; Weigel, P.H.
    Purification and lipid dependence of the recombinant hyaluronan synthases from Streptococcus pyogenes and Streptococcus equisimilis (1999), J. Biol. Chem., 274, 4239-4245.
    View publication on PubMed
Search for more literature for 2.4.1.212

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Streptococcus dysgalactiae subsp. equisimilis
expression in Escherichia coli Streptococcus pyogenes

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.04
-
 UDP-D-glucuronate
-
 Streptococcus pyogenes
0.051
-
 UDP-D-glucuronate
-
 Streptococcus dysgalactiae subsp. equisimilis
0.06
-
 UDP-N-acetyl-D-glucosamine
-
 Streptococcus dysgalactiae subsp. equisimilis
0.149
-
 UDP-N-acetyl-D-glucosamine
-
 Streptococcus pyogenes

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane
-
 Streptococcus pyogenes 16020
-

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
47780
-
 calculation from sequence Streptococcus dysgalactiae subsp. equisimilis
47780
-
 calculation from sequence Streptococcus pyogenes

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate Streptococcus dysgalactiae subsp. equisimilis
-
 [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
 ?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate Streptococcus pyogenes
-
 [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
 ?

Organism

Organism UniProt Comment Textmining
Streptococcus dysgalactiae subsp. equisimilis
-
-
-
Streptococcus pyogenes
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
-
 Streptococcus dysgalactiae subsp. equisimilis [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
 ?
UDP-N-acetyl-D-glucosamine + UDP-D-glucuronate
-
 Streptococcus pyogenes [beta-N-acetyl-D-glucosaminyl(1-4)beta-D-glucuronosyl(1-3)]n + UDP
-
 ?