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Literature summary for 2.4.1.206 extracted from

  • Kuan, C.T.; Chang, J.; Mansson, J.E.; Li, J.; Pegram, C.; Fredman, P.; McLendon, R.E.; Bigner, D.D.
    Multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase - a key enzyme in lacto-neolacto ganglioside synthesis (2010), BMC Dev. Biol., 10, 114.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene B3gnt5, chromosome 16 B1 Mus musculus

Protein Variants

Protein Variants Comment Organism
additional information generation of Lc3 synthase gene B3gnt5-deficient knockout mice, phenotypes, overview Mus musculus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Mus musculus Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides ?
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?
additional information Mus musculus C57BL/6 Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides ?
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?

Organism

Organism UniProt Comment Textmining
Mus musculus
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gene B3gnt5
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Mus musculus C57BL/6
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gene B3gnt5
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Source Tissue

Source Tissue Comment Organism Textmining
cerebellum
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Mus musculus
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embryo E17 fetus, both head and body show strong expression of Lc3 synthase in wild-type (Wt/Wt) and heterozygous (Wt/KO) mice Mus musculus
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placenta
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Mus musculus
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spleen
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Mus musculus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides Mus musculus ?
-
?
additional information Lc3 synthase utilizes a variety of galactose-terminated glycolipids as acceptors by establishing a glycosidic bond in the beta-1,3-linkage to GlcNaAc to extend the lacto- and neolacto-series gangliosides Mus musculus C57BL/6 ?
-
?

Synonyms

Synonyms Comment Organism
Lc3 synthase
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Mus musculus

General Information

General Information Comment Organism
evolution Lc3 synthase is a member of the beta-1,3-N-glycosyltransferase superfamily Mus musculus
malfunction multiple phenotypic changes in mice after knockout of the B3gnt5 gene, encoding Lc3 synthase, detailed overview. B3gnt5 gene knockout mutant mice appear normal in the embryonic stage and, if they survive delivery, remain normal during early life, but about 9% develop early-stage growth retardation, 11% die postnatally in less than 2 months, and adults tend to die in 5-15 months, demonstrating splenomegaly and notably enlarged lymph nodes. Without lacto-neolacto series gangliosides, both homozygous and heterozygous mice gradually display fur loss or obesity, and breeding mice demonstrate reproductive defects. B3gnt5 gene knockout disrupts the functional integrity of B cells with a decrease in B-cell numbers in the spleen, germinal center disappearance, and less efficiency to proliferate in hybridoma fusion Mus musculus
metabolism Lc3 synthase acts within the gangliosynthesis pathways, overview Mus musculus
physiological function Lc3 synthase is a key enzyme in lacto-neolacto ganglioside synthesis, it exhibits strong activity in transferring GlcNAc to the lactosylceramide for lacto-neolacto-chain ganglioside biosynthesis, regulated during embryonic development, especially during brain morphogenesis Mus musculus