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Literature summary for 2.4.1.173 extracted from

  • Oku, M.; Warnecke, D.; Noda, T.; Muller, F.; Heinz, E.; Mukaiyama, H.; Kato, N.; Sakai, Y.
    Peroxisome degradation requires catalytically active sterol glucosyltransferase with a GRAM domain (2003), EMBO J., 22, 3231-3241.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.173

Cloned(Commentary)

Cloned (Comment) Organism
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 Komagataella pastoris

Protein Variants

Protein Variants Comment Organism
Y642P amino acid substitution within the GRAM domain abolished this association as well as micropexophagy Komagataella pastoris

Localization

Localization Comment Organism GeneOntology No. Textmining
membrane during micropexophagy, the glucosyltransferase is associated with the micropexophagic apparatus. GRAM domain is essential for proper protein association with its target membrane Komagataella pastoris 16020
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micropexophagic apparatus during micropexophagy, the glucosyltransferase is associated with the micropexophagic apparatus. GRAM domain is essential for proper protein association with its target membrane Komagataella pastoris
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-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Komagataella pastoris sterol glucosyltransferase Ugt51/Paz4 is essential for pexophagy (peroxisome degradation), but not for macroautophagy in the methylotrophic yeast. Deletion of the catalytic domain does not impair protein localization, but abolishes pexophagy, suggesting that SG synthesis is required for this process ?
-
 ?
additional information Komagataella pastoris GS115 sterol glucosyltransferase Ugt51/Paz4 is essential for pexophagy (peroxisome degradation), but not for macroautophagy in the methylotrophic yeast. Deletion of the catalytic domain does not impair protein localization, but abolishes pexophagy, suggesting that SG synthesis is required for this process ?
-
 ?

Organism

Organism UniProt Comment Textmining
Komagataella pastoris Q9Y751
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-
Komagataella pastoris GS115 Q9Y751
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information sterol glucosyltransferase Ugt51/Paz4 is essential for pexophagy (peroxisome degradation), but not for macroautophagy in the methylotrophic yeast. Deletion of the catalytic domain does not impair protein localization, but abolishes pexophagy, suggesting that SG synthesis is required for this process Komagataella pastoris ?
-
 ?
additional information sterol glucosyltransferase Ugt51/Paz4 is essential for pexophagy (peroxisome degradation), but not for macroautophagy in the methylotrophic yeast. Deletion of the catalytic domain does not impair protein localization, but abolishes pexophagy, suggesting that SG synthesis is required for this process Komagataella pastoris GS115 ?
-
 ?

Synonyms

Synonyms Comment Organism
sterol glucosyltransferase Ugt51/Paz4
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 Komagataella pastoris
Ugt51
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 Komagataella pastoris
Ugt51/Paz4
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 Komagataella pastoris