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Literature summary for 2.4.1.17 extracted from

  • Chau, N.; Elliot, D.J.; Lewis, B.C.; Burns, K.; Johnston, M.R.; Mackenzie, P.I.; Miners, J.O.
    Morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7: kinetic, inhibition, and molecular modeling studies (2014), J. Pharmacol. Exp. Ther., 349, 126-137.
    View publication on PubMed
Search for more literature for 2.4.1.17

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose ?
-
 ?
UDP-glucuronate + morphine Homo sapiens
-
 UDP + morphine-3-beta-D-glucuronide
-
 ?
UDP-glucuronate + morphine Homo sapiens
-
 UDP + morphine-6-beta-D-glucuronide
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P16662
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose Homo sapiens ?
-
 ?
UDP-glucuronate + morphine
-
 Homo sapiens UDP + morphine-3-beta-D-glucuronide
-
 ?
UDP-glucuronate + morphine
-
 Homo sapiens UDP + morphine-6-beta-D-glucuronide
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 2B7
-
 Homo sapiens

General Information

General Information Comment Organism
metabolism morphine glucuronidation and glucosidation represent complementary metabolic pathways that are both catalyzed by UDP-glucuronosyltransferase 2B7. Glucuronidation is the dominant metabolic pathway because the binding affinity of UDP-glucuronic acid to UGT2B7 is higher than that of UDPglucose. Morphine-3-beta-D-glucuronide and morphine-6-beta-D-glucuronide are the major metabolites of morphine in humans Homo sapiens