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Literature summary for 2.4.1.17 extracted from

  • Troberg, J.; Jaervinen, E.; Muniz, M.; Sneitz, N.; Mosorin, J.; Hagstroem, M.; Finel, M.
    Dog UDP-glucuronosyltransferase enzymes of subfamily 1A: cloning, expression, and activity (2015), Drug Metab. Dispos., 43, 107-118.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
gene UGT1A1, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A1, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A10, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A10, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A11, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A2, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A3, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A3, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A4, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A4, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A5, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A6, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A6, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A7, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A7, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A8, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A8, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris
gene UGT1A9, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of dog and human UGT1As Homo sapiens
gene UGT1A9, cloning from genomic DNA and hepatic cDNA, phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Canis lupus familiaris
-
-
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Canis lupus familiaris
-
 beagle dogs
-
Canis lupus familiaris Q95M37 beagle dogs
-
Homo sapiens O60656
-
-
Homo sapiens P19224
-
-
Homo sapiens P22309
-
-
Homo sapiens P22310
-
-
Homo sapiens P35503
-
-
Homo sapiens P35504
-
-
Homo sapiens Q9HAW7
-
-
Homo sapiens Q9HAW8
-
-
Homo sapiens Q9HAW9
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Canis lupus familiaris
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2 UDP-D-glucuronate + 2 dexmedetomidine low activity Homo sapiens 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
-
 ?
2 UDP-D-glucuronate + 2 dexmedetomidine veryl low activity Homo sapiens 2 UDP + dexmedetomidine N1-beta-D-glucuronoside + dexmedetomidine N3-beta-D-glucuronoside
-
 ?
additional information no activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, entacapone, levomedetomidine, diclofenac, indomethacin, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no activity with bilirubin, 4-methylumbelliferone, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no activity with bilirubin, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no activity with bilirubin, ethinylestradiol, 17-beta-estradiol, dexmedetomidine, and levomedetomidine, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no activity with bilirubin, ethinylestradiol, 17beta- and 17alpha-estradiol, diclofenac, entacapone, 4-methylumbelliferone, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no activity with dexmedetomidine, levomedetomidine, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no or poor activity with 4-methylumbelliferone, dexmedetomidine, levomedetomidine, and S-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with bilirubin, 17-alpha-estradiol, 17-beta-estradiol, dexmedetomidine, levomedetomidine, diclofenac, indomethacin, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no or poor activity with bilirubin, dexmedetomidine, diclofenac, levomedetomidine, (R)-propranolol, (S)-propranolol, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no or poor activity with bilirubin, ethinylestradiol, 17-alpha-estradiol, 17-beta-estradiol, levomedetomidine, dexmedetomidine, diclofenac, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with bilirubin, levomedetomidine, and dexmedetomidine, substrate specificities of isozymes, overview Homo sapiens ?
-
 ?
additional information no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, and (R)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with bilirubin, levomedetomidine, dexmedetomidine, indomethacin, and (S)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with bilirubin,levomedetomidine, dexmedetomidine, diclofenac, 4-methylumbelliferone, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
additional information no or poor activity with levomedetomidine, 4-methylumbelliferone, dexmedetomidine, (R)-propranolol, and (S)-propranolol, substrate specificities of isozymes, overview Canis lupus familiaris ?
-
 ?
UDP-alpha-D-glucuronate + (R)-propranolol
-
 Canis lupus familiaris UDP + (R)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (R)-propranolol
-
 Homo sapiens UDP + (R)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (R)-propranolol high activity Homo sapiens UDP + (R)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (S)-propranolol
-
 Canis lupus familiaris UDP + (S)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (S)-propranolol
-
 Homo sapiens UDP + (S)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (S)-propranolol very low activity Canis lupus familiaris UDP + (S)-propranolol beta-D-glucuronoside
-
 ?
UDP-alpha-D-glucuronate + (S)-propranolol high activity Homo sapiens UDP + (S)-propranolol beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol
-
 Canis lupus familiaris UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol very low activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol low activity Canis lupus familiaris UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol low activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol good substrate Canis lupus familiaris UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol lower activity Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol higher activity Canis lupus familiaris UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-alpha-estradiol very high activity with UGT1A10 Homo sapiens UDP + 17-alpha-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol
-
 Canis lupus familiaris UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol low activity Canis lupus familiaris UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol low activity Homo sapiens UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol lower activity Homo sapiens UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 17-beta-estradiol very high activity Homo sapiens UDP + 17-beta-estradiol 3-O-beta-D-glucuronoside
-
 ?
UDP-glucuronate + 4-methylumbelliferone
-
 Canis lupus familiaris UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
UDP-glucuronate + 4-methylumbelliferone
-
 Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
UDP-glucuronate + 4-methylumbelliferone low activity Canis lupus familiaris UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
UDP-glucuronate + 4-methylumbelliferone high activity Homo sapiens UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
UDP-glucuronate + 4-methylumbelliferone high activity Canis lupus familiaris UDP + 4-methylumbelliferyl beta-D-glucuronoside
-
 ?
UDP-glucuronate + bilirubin
-
 Canis lupus familiaris UDP + bilirubin beta-D-glucuronoside
-
 ?
UDP-glucuronate + bilirubin very low activity Canis lupus familiaris UDP + bilirubin beta-D-glucuronoside
-
 ?
UDP-glucuronate + bilirubin very high activity Homo sapiens UDP + bilirubin beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac
-
 Canis lupus familiaris UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac very low activity Canis lupus familiaris UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac very low activity Homo sapiens UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac low activity Canis lupus familiaris UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac low activity Homo sapiens UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + diclofenac high activity Homo sapiens UDP + diclofenac beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone
-
 Canis lupus familiaris UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone very low activity Homo sapiens UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone low activity Homo sapiens UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone high activity Canis lupus familiaris UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone high activity Homo sapiens UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + entacapone very high activity Homo sapiens UDP + entacapone beta-D-glucuronoside
-
 ?
UDP-glucuronate + epitestosterone
-
 Canis lupus familiaris UDP + epitestosterone beta-D-glucuronoside
-
 ?
UDP-glucuronate + epitestosterone
-
 Homo sapiens UDP + epitestosterone beta-D-glucuronoside
-
 ?
UDP-glucuronate + ethinylestradiol
-
 Canis lupus familiaris UDP + ethinylestradiol beta-D-glucuronoside
-
 ?
UDP-glucuronate + ethinylestradiol
-
 Homo sapiens UDP + ethinylestradiol beta-D-glucuronoside
-
 ?
UDP-glucuronate + ethinylestradiol very low activity Canis lupus familiaris UDP + ethinylestradiol beta-D-glucuronoside
-
 ?
UDP-glucuronate + ethinylestradiol very low activity Homo sapiens UDP + ethinylestradiol beta-D-glucuronoside
-
 ?
UDP-glucuronate + ethinylestradiol low activity Canis lupus familiaris UDP + ethinylestradiol beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin
-
 Canis lupus familiaris UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin
-
 Homo sapiens UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin very low activity Homo sapiens UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin low activity Canis lupus familiaris UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin low activity Homo sapiens UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + indomethacin high activity Homo sapiens UDP + indomethacin beta-D-glucuronoside
-
 ?
UDP-glucuronate + levomedetomidine
-
 Homo sapiens UDP + levomedetomidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + levomedetomidine low activity Homo sapiens UDP + levomedetomidine beta-D-glucuronoside
-
 ?
UDP-glucuronate + testosterone
-
 Canis lupus familiaris UDP + testosterone beta-D-glucuronoside
-
 ?
UDP-glucuronate + testosterone
-
 Homo sapiens UDP + testosterone beta-D-glucuronoside
-
 ?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Canis lupus familiaris
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT1A1
-
 Canis lupus familiaris
UGT1A1
-
 Homo sapiens
UGT1A10
-
 Canis lupus familiaris
UGT1A10
-
 Homo sapiens
UGT1A11
-
 Canis lupus familiaris
UGT1A2
-
 Canis lupus familiaris
UGT1A3
-
 Canis lupus familiaris
UGT1A3
-
 Homo sapiens
UGT1A4
-
 Canis lupus familiaris
UGT1A4
-
 Homo sapiens
UGT1A5
-
 Homo sapiens
UGT1A6
-
 Homo sapiens
UGT1A6
-
 Canis lupus familiaris
UGT1A7
-
 Canis lupus familiaris
UGT1A7
-
 Homo sapiens
UGT1A8
-
 Canis lupus familiaris
UGT1A8
-
 Homo sapiens
UGT1A9
-
 Canis lupus familiaris
UGT1A9
-
 Homo sapiens

General Information

General Information Comment Organism
evolution phylogenetic analysis of dog and human UGT1As Homo sapiens
evolution phylogenetic analysis of the dog and human UGT1As Canis lupus familiaris