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Literature summary for 2.4.1.17 extracted from

  • Dong, R.H.; Fang, Z.Z.; Zhu, L.L.; Ge, G.B.; Yang, L.; Liu, Z.Y.
    Identification of UDP-glucuronosyltransferase isoforms involved in hepatic and intestinal glucuronidation of phytochemical carvacrol (2012), Xenobiotica, 42, 1009-1016.
    View publication on PubMed
Search for more literature for 2.4.1.17

Cloned(Commentary)

Cloned (Comment) Organism
expression in insect cell Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
propofol
-
 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.071
-
 carvacrol isoform UGT1A3, pH 7.4, 37°C Homo sapiens
0.078
-
 carvacrol isoform UGT1A9, pH 7.4, 37°C Homo sapiens
0.14
-
 carvacrol isoform UGT1A6, pH 7.4, 37°C Homo sapiens
0.282
-
 carvacrol isoform UGT1A7, pH 7.4, 37°C Homo sapiens
0.368
-
 carvacrol isoform UGT2B7, pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
 Homo sapiens
-
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
 Homo sapiens
-
liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
carvacrol + UDP-glucuronate isoform UGT1A9 is the major isozyme responsible for glucuronidation in liver microsomes, and isoform UGT1A7 plays a major role for glucuronidation in intestinal microsomes Homo sapiens caervcrol O-glucuronate + UDP
-
 ?

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.154
-
 substrate carvacrol, isoform UGT1A7, pH 7.4, 37°C Homo sapiens propofol
0.194
-
 substrate carvacrol, isoform UGT1A9, pH 7.4, 37°C Homo sapiens propofol