Protein Variants | Comment | Organism |
---|---|---|
F83L | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
G71R | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
I294T | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
N400D | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
R336L | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
W461R | mutant of isoform UGT1A1, comparison of the substrate hydroxyl orientation with the values for in vitro conjugation capacity | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
bilirubin + UDP-glucuronate | - |
Homo sapiens | bilirubin D-glucuronate + UDP | - |
? | |
additional information | the orientation of the substrate correlates with the conjugation capacity in in vitro experiments. As glucuronidation is an intermolecular rearrangement reaction, the conjugation reaction proceeds only when the hydroxyl group of the substrate is oriented towards the coenzyme, which allows the proton transfer to occur | Homo sapiens | ? | - |
? |