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Literature summary for 2.4.1.17 extracted from

  • Basu, N.K.; Kole, L.; Basu, M.; Chakraborty, K.; Mitra, P.S.; Owens, I.S.
    The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C (2008), J. Biol. Chem., 283, 23048-23061.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 2.4.1.17

Activating Compound

Activating Compound Comment Organism Structure
additional information the regulatory domain of PKC leading to activation, and H2O2 activates PKC via increased phosphorylation of tyrosine in its catalytic domain Homo sapiens

Cloned(Commentary)

Cloned (Comment) Organism
expression of UGT isozymes in COS-1 cells with co-localization of isozyme UGT1A7His and PKCepsilon and of isoyzme UGT1A10His andPKCalpha orPKCgamma Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
calphostin-C
-
 Homo sapiens
curcumin reversable by low glucuronidation activity with curcumin as substrate, overview Homo sapiens
additional information inhibition of UGT activity by PKCepsilon-specific antagonist peptide or by PKCapsilon-targeted destruction with PKCepsilon-specific small interference RNA and activation of curcumin-down-regulated UGTs with typical PKC agonists verify a central PKC role in glucuronidation, overview. UGT down-regulation by the tyrosine kinase-specific inhibitor, herbimycin-A, suggests cellular oxidant-/H2O2-activated PKC via tyrosine phosphorylation also plays a role in sustaining UGT activity Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
endoplasmic reticulum co-localization of UGTs with protein kinases C, overview Homo sapiens 5783
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + acceptor Homo sapiens protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview UDP + acceptor beta-D-glucuronoside
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
phosphoprotein UGT isozymes are phosphorylated by active protein kinases Cepsilon, Calpha, and Cgamma, analysis of UGT phosphorylation, overview Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
colon
-
 Homo sapiens
-
gastrointestinal tract
-
 Homo sapiens
-
kidney
-
 Homo sapiens
-
liver
-
 Homo sapiens
-
LS-180 cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information specific phospho-groups in UGT1A7 determine substrate selections, suggests regulated phosphorylation allows adaptations regarding differential phosphate utilization by UGTs to function efficiently Homo sapiens ?
-
 ?
UDP-D-glucuronate + 4-nitrophenol
-
 Homo sapiens UDP + 4-nitrophenyl beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + 5alpha-androstane-3alpha,17beta-diol
-
 Homo sapiens UDP + ?
-
 ?
UDP-D-glucuronate + acceptor
-
 Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + acceptor protein kinases are involved in UGT regulation, UGTs inactivate aromatic-like metabolites and a vast number of dietary and environmental chemicals, which reduces the risk of toxicities, mutagenesis, and carcinogenesis, primarily in liver, kidney, and gastrointestinal tract, overview Homo sapiens UDP + acceptor beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + anthraflavic acid
-
 Homo sapiens UDP + ?
-
 ?
UDP-D-glucuronate + apigenin
-
 Homo sapiens UDP + apigenin 7-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + bilirubin
-
 Homo sapiens UDP + ?
-
 ?
UDP-D-glucuronate + capsaicin
-
 Homo sapiens UDP + capsaicin beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + curcumin low activity, can reverse the inhibitory effect of curcumin on UGTs Homo sapiens UDP + curcumin beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + estriol
-
 Homo sapiens UDP + estriol 3-O-beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + eugenol
-
 Homo sapiens UDP + eugenol beta-D-glucuronoside
-
 ?
UDP-D-glucuronate + phenolphthalein
-
 Homo sapiens UDP + phenolphthalein beta-D-monoglucuronoside
-
 ?
UDP-D-glucuronate + phloretin
-
 Homo sapiens UDP + ?
-
 ?

Subunits

Subunits Comment Organism
? x * 52000-55000, SDS-PAGE Homo sapiens

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase
-
 Homo sapiens
UGT
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Range

pH Minimum pH Maximum Comment Organism
6.4 7.6
-
 Homo sapiens