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Literature summary for 2.4.1.17 extracted from

  • Liu, H.X.; Liu, Y.; Zhang, J.W.; Li, W.; Liu, H.T.; Yang, L.
    UDP-glucuronosyltransferase 1A6 is the major isozyme responsible for protocatechuic aldehyde glucuronidation in human liver microsomes (2008), Drug Metab. Dispos., 36, 1562-1569.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
androsterone inhibits protocatechuic aldehyde glucuronidation by isozyme UGT1A9 and slightly by liver microsomes Homo sapiens
Phenylbutazone inhibits protocatechuic aldehyde glucuronidation by isozyme UGT1A6 and liver microsomes Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
additional information
-
additional information kinetics analysis using ecombinant isozymes UGT1A6 and UGT1A9, and liver and intestine microsomes, overview Homo sapiens
0.211
-
Protocatechuic aldehyde pH 7.5, 37°C, recombinant isozyme UGT1A6, formation of product M2 Homo sapiens
0.2385
-
Protocatechuic aldehyde pH 7.5, 37°C, recombinant isozyme UGT1A9, formation of product M2 Homo sapiens
0.337
-
Protocatechuic aldehyde pH 7.5, 37°C, liver microsomes, formation of product M2 Homo sapiens
0.3675
-
Protocatechuic aldehyde pH 7.5, 37°C, recombinant isozyme UGT1A6, formation of product M1 Homo sapiens
0.38
-
Protocatechuic aldehyde pH 7.5, 37°C, recombinant isozyme UGT1A9, formation of product M1 Homo sapiens
0.433
-
Protocatechuic aldehyde pH 7.5, 37°C, liver microsomes, formation of product M1 Homo sapiens
0.494
-
Protocatechuic aldehyde pH 7.5, 37°C, intestine microsomes, formation of product M2 Homo sapiens
0.627
-
Protocatechuic aldehyde pH 7.5, 37°C, intestine microsomes, formation of product M1 Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
microsome
-
Homo sapiens
-
-

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
UDP-D-glucuronate + acceptor Homo sapiens
-
UDP + acceptor beta-D-glucuronoside
-
?
UDP-D-glucuronate + protocatechuic aldehyde Homo sapiens
-
UDP + ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens P19224
-
-

Source Tissue

Source Tissue Comment Organism Textmining
intestine
-
Homo sapiens
-
liver
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
UDP-D-glucuronate + acceptor
-
Homo sapiens UDP + acceptor beta-D-glucuronoside
-
?
UDP-D-glucuronate + protocatechuic aldehyde
-
Homo sapiens UDP + ?
-
?
UDP-D-glucuronate + protocatechuic aldehyde i.e. 3,4-dihydroxybenzaldehyde, the reaction is catalyzed by recombinant isozyme UGT1A6, especially, and also by isozyme UGT1A9, as well as by liver and intestine microsomes, overview Homo sapiens UDP + ?
-
?

Synonyms

Synonyms Comment Organism
UDP-glucuronosyltransferase 1A6
-
Homo sapiens
UGT1A6
-
Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
assay at Homo sapiens

IC50 Value

IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
0.0271
-
pH 7.5, 37°C, recombinant isozyme UGT1A9 Homo sapiens androsterone
0.0455
-
pH 7.5, 37°C, recombinant isozyme UGT1A6 Homo sapiens Phenylbutazone
0.0619
-
pH 7.5, 37°C, liver microsomes Homo sapiens Phenylbutazone