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Literature summary for 2.4.1.17 extracted from
- Identification and characterization of functional hepatocyte nuclear factor 1-binding sites in UDP-glucuronosyltransferase genes (2005), Methods Enzymol., 400, 22-46.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 2 | - |
acetaminophen | - |
Homo sapiens |  |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | P19224 | - |
- |
| Rattus norvegicus | P08430 | - |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| brain | - |
Homo sapiens | - |
| brain | mostly in the hippocampus and cerebellum | Rattus norvegicus | - |
| Caco-2 cell | - |
Homo sapiens | - |
| colon | - |
Homo sapiens | - |
| colon | - |
Rattus norvegicus | - |
| duodenum | - |
Homo sapiens | - |
| duodenum | - |
Rattus norvegicus | - |
| esophagus | - |
Rattus norvegicus | - |
| intestine | - |
Homo sapiens | - |
| intestine | - |
Rattus norvegicus | - |
| jejunum | - |
Homo sapiens | - |
| jejunum | - |
Rattus norvegicus | - |
| kidney | - |
Homo sapiens | - |
| kidney | - |
Rattus norvegicus | - |
| larynx | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
| liver | constitutively expressed with high interindividual variability of human liver enzyme levels is due to a number of influences, including genetic, tissue-specific, and environmental factors. Homo- and heterozygotic expression of UGT1A6 alleles markedly affects enzyme activity. HNF1 may be responsible for tissue-specific UGT1A6 expression. Multiple environmental factors controll UGT1A6 expression, including the pregnane X receptor, the constitutive androstane receptor, the aryl hydrocarbon receptor, and Nrf2, a bZIP transcription factor mediating stress responses | Homo sapiens | - |
| lung | - |
Homo sapiens | - |
| lung | - |
Rattus norvegicus | - |
| ovary | - |
Rattus norvegicus | - |
| stomach | - |
Homo sapiens | - |
| stomach | - |
Rattus norvegicus | - |
| testis | - |
Homo sapiens | - |
| testis | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acetaminophen + UDP-glucuronate | - |
Rattus norvegicus | ? | - |
? | |
| acetaminophen + UDP-glucuronate | with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9 | Homo sapiens | ? | - |
? | |
| benzo[a]pyrene 3,6-diphenol + UDP-glucuronate | converted readily to mono- and diglucuronides | Rattus norvegicus | ? | - |
? | |
| serotonin + UDP-glucuronate | - |
Rattus norvegicus | UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide | - |
? | |
| serotonin + UDP-glucuronate | highly selective substrate of UGT1A6 in human liver microsomes, with human UGT1A6, only monoglucuronides are formed, which, however, can be converted to diglucuronides by UGT1A9 | Homo sapiens | UDP + 3-(2-aminoethyl)-1H-indol-5-yl beta-D-glucuronide | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| UGT1A6 | - |
Homo sapiens |
| UGT1A6 | - |
Rattus norvegicus |
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Release 2023.1 (January 2023)
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