Application | Comment | Organism |
---|---|---|
medicine | UGT1A10 codon 139 polymorphism may be an important determinant in risk for tobacco-related cancers | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
- |
Homo sapiens |
stable HEK293 cell lines overexpressing either the UGT1A10139Glu or UGT1A10139Lys isoforms are created | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
E139K | the nonconservative amino change of Glu to Lys at codon 139 renders UGT1A10 less active | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0097 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0098 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0113 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0299 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0301 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0342 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0382 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0501 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0556 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0621 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0633 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0635 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.087 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0918 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.0963 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.115 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.125 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.127 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.129 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.169 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.19 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.208 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.209 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.234 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.281 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.295 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.348 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.481 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.497 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.542 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.583 | - |
3-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.615 | - |
9-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
0.854 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
1.526 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
1.588 | - |
7-hydroxy benzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens | |
2.869 | - |
1-hydroxybenzo(a)pyrene | 37°C, pH 7.5 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + acceptor | Homo sapiens | UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons | UDP + acceptor beta-D-glucuronoside | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O60656 | recombinant | - |
Homo sapiens | O75795 | recombinant | - |
Homo sapiens | P16662 | recombinant | - |
Homo sapiens | P22309 | recombinant | - |
Homo sapiens | P35503 | recombinant | - |
Homo sapiens | P54855 | recombinant | - |
Homo sapiens | Q9HAW7 | recombinant | - |
Homo sapiens | Q9HAW8 | - |
- |
Homo sapiens | Q9HAW9 | recombinant | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
lung | - |
Homo sapiens | - |
oral squamous cell carcinoma cell line | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
1-hydroxybenzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
1-hydroxybenzo(a)pyrene + UDP-glucuronate | UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member | Homo sapiens | ? | - |
? | |
1-naphthol + UDP-glucuronate | - |
Homo sapiens | 1-naphthyl-O-glucuronide + UDP | - |
? | |
3-hydroxybenzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
3-hydroxybenzo(a)pyrene + UDP-glucuronate | UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member | Homo sapiens | ? | - |
? | |
4-methylumbelliferone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-methylumbelliferyl-7-O-beta-D-glucuronide | - |
? | |
4-nitrophenol + UDP-glucuronate | - |
Homo sapiens | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
7-hydroxy benzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
7-hydroxy benzo(a)pyrene + UDP-glucuronate | UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member | Homo sapiens | ? | - |
? | |
9-hydroxybenzo(a)pyrene + UDP-glucuronate | - |
Homo sapiens | ? | - |
? | |
9-hydroxybenzo(a)pyrene + UDP-glucuronate | UGT1A10 exhibited considerably more glucuronidation activity than any other glucuronosyltransferase UGT1A family member | Homo sapiens | ? | - |
? | |
UDP-glucuronate + acceptor | UGT1A10 is an important detoxifier of polycyclic aromatic hydrocarbons | Homo sapiens | UDP + acceptor beta-D-glucuronoside | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UDP-glucuronosyltransferase 1A1 | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A10 | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A3 | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A7 | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A8 | - |
Homo sapiens |
UDP-glucuronosyltransferase 1A9 | - |
Homo sapiens |
UDP-glucuronosyltransferase 2B15 | - |
Homo sapiens |
UDP-glucuronosyltransferase 2B17 | - |
Homo sapiens |
UDP-glucuronosyltransferase 2B7 | - |
Homo sapiens |
UGT1A1 | - |
Homo sapiens |
UGT1A10 | - |
Homo sapiens |
UGT1A3 | - |
Homo sapiens |
UGT1A7 | - |
Homo sapiens |
UGT1A8 | - |
Homo sapiens |
UGT1A9 | - |
Homo sapiens |
UGT2B15 | - |
Homo sapiens |
UGT2B17 | - |
Homo sapiens |
UGT2B7 | - |
Homo sapiens |