Activating Compound | Comment | Organism | Structure |
---|---|---|---|
UDP-GlcNAc | stimulates | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
expression in COS7 cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
C127C | mutation results in loss of UGT1A1 activity | Homo sapiens |
C156R | mutation results in loss of UGT1A1 activity | Homo sapiens |
C177Y | mutation results in loss of UGT1A1 activity | Homo sapiens |
C186C | although the activity of the C186Y mutant UGT1A1 is reduced to 50% of normal, the enzyme activity increases proportionately in the presence of UDPGlcNAc | Homo sapiens |
C186Y | 45% of wild-type activity with bilirubin as substrate | Homo sapiens |
C223Y | mutation results in loss of UGT1A1 activity | Homo sapiens |
C280Y | mutation results in loss of UGT1A1 activity | Homo sapiens |
C384Y | mutation results in loss of UGT1A1 activity | Homo sapiens |
C509Y | 75% of wild-type activity with bilirubin as substrate | Homo sapiens |
C510Y | 80% of wild-type activity with bilirubin as substrate | Homo sapiens |
C517Y | 85% of wild-type activity with bilirubin as substrate | Homo sapiens |
Q357R | mutation results in loss of UGT1A1 activity | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P22309 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
UDP-glucuronate + bilirubin | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
UGT1A1 | - |
Homo sapiens |