Protein Variants | Comment | Organism |
---|---|---|
I96R | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
I96R | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
I96R/T98I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
I96R/T98I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
I98T | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
I98T | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
L93I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
L93I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
R96I | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
R96I | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
R96I/I98T | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
R96I/I98T | UGT2B15 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
S100G | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
S100G | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
T98I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
T98I | UGT2B20 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
T98I | UGT2B17 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
T98I | UGT2B17 activity retained for 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
additional information | - |
additional information | kinetic analysis of UGT2B15, UGT2B17 and UGT2B20 mutant proteins for 5 alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini | |
additional information | - |
additional information | kinetic analysis of UGT2B15, UGT2B17 and UGT2B20 mutant proteins for 5 alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
microsome | - |
Platyrrhini | - |
- |
microsome | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | O75795 | - |
- |
Platyrrhini | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | UGT2B7 UGT2B15, UGT2B17 and UGT2B20 | Platyrrhini |
glycoprotein | UGT2B7 UGT2B15, UGT2B17 and UGT2B20 | Homo sapiens |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Platyrrhini |
additional information | - |
activities of wild-type and glycosylation mutant of UGT2B15 and UGT2B20 on 5alpha-androstane-3alpha-17beta-diol, dihydrotestosterone and testosterone | Homo sapiens |