Cloned (Comment) | Organism |
---|---|
expressed in HK293 cells | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2-hydroxyestradiol | inhibits 4-hydroxyestradiol glucuronidation catalyzed by UGT2B7Y | Homo sapiens | |
4-hydroxyestradiol | inhibits 2-hydroxyestradiol glucuronidation catalyzed by UGT1A1 | Homo sapiens | |
flunitrazepam | competitive inhibition of estrogen and buprenorphine catalyzed by UGT1A1 and UGT2B7Y, not inhibition of UGT1A3 | Homo sapiens | |
additional information | norepinephrine does not inhibit UGT2B7Y, UGT1A1 nor UGT1A3 | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.006 | - |
4-hydroxyestradiol | apparent Km on expressed UGT1A1, 2 mM UDP glucuronic acid | Homo sapiens | |
0.007 | - |
4-hydroxyestradiol | apparent Km on expressed UGT2B7Y, 2 mM UDP glucuronic acid | Homo sapiens | |
0.014 | - |
2-hydroxyestradiol | apparent Km on expressed UGT2B7Y, 2 mM UDP glucuronic acid | Homo sapiens | |
0.016 | - |
4-hydroxyestrone | apparent Km on expressed UGT2B7Y, 2 mM UDP glucuronic acid | Homo sapiens | |
0.019 | - |
4-hydroxyestrone | apparent Km on expressed UGT1A1, 2 mM UDP glucuronic acid | Homo sapiens | |
0.024 | - |
2-hydroxyestrone | apparent Km on expressed UGT1A3, 2 mM UDP glucuronic acid | Homo sapiens | |
0.026 | - |
2-hydroxyestrone | apparent Km on expressed UGT1A1, 2 mM UDP glucuronic acid | Homo sapiens | |
0.026 | - |
2-hydroxyestradiol | apparent Km on expressed UGT1A3, 2 mM UDP glucuronic acid | Homo sapiens | |
0.027 | - |
2-hydroxyestradiol | apparent Km on expressed UGT1A1, 2 mM UDP glucuronic acid | Homo sapiens | |
0.038 | - |
4-hydroxyestradiol | apparent Km on expressed UGT1A3, 2 mM UDP glucuronic acid | Homo sapiens | |
0.053 | - |
4-hydroxyestrone | apparent Km on expressed UGT1A3, 2 mM UDP glucuronic acid | Homo sapiens | |
0.066 | - |
2-hydroxyestrone | apparent Km on expressed UGT2B7Y, 2 mM UDP glucuronic acid | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
nuclear membrane | - |
Homo sapiens | 31965 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
liver | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
2-hydroxyestradiol + UDPglucuronate | - |
Homo sapiens | UDP + 2-hydroxyestradiol O-glucuronide | - |
? | |
2-hydroxyestrone + UDPglucuronate | - |
Homo sapiens | 2-hydroxyestrone 2-O-glucuronide + UDP | - |
? | |
4-hydroxyestradiol + UDPglucuronate | - |
Homo sapiens | UDP + 4-hydroxyestradiol O-glucuronide | - |
? | |
4-hydroxyestrone + UDP-glucuronate | - |
Homo sapiens | UDP + 4-hydroxyestrone 4-O-glucuronide | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.022 | - |
flunitrazepam | inhibition of 2-hydroxyestrone glucuronidation catalyzed by UGT1A3 | Homo sapiens | |
0.03 | - |
flunitrazepam | inhibition of 2-hydroxyestradiol glucuronidation catalyzed by UGT1A3 | Homo sapiens | |
0.047 | - |
flunitrazepam | inhibition of nalorphine glucuronidation catalyzed by UGT2B7Y | Homo sapiens | |
0.052 | - |
flunitrazepam | inhibition of 4-hydroxyestrone glucuronidation catalyzed by UGT2B7Y | Homo sapiens | |
0.061 | - |
flunitrazepam | inhibition of 4-hydroxyestradiol glucuronidation catalyzed by UGT2B7Y | Homo sapiens | |
0.093 | - |
flunitrazepam | inhibition of buprenorphine glucuronidation catalyzed by UGT2B7Y | Homo sapiens | |
0.206 | - |
flunitrazepam | inhibition of buprenorphine glucuronidation catalyzed by UGT1A1 | Homo sapiens | |
0.402 | - |
flunitrazepam | inhibition of 2-hydroxyestradiol glucuronidation catalyzed by UGT1A1 | Homo sapiens | |
0.808 | - |
flunitrazepam | inhibition of 2-hydroxyestrone glucuronidation catalyzed by UGT1A1 | Homo sapiens |