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Literature summary for 2.4.1.17 extracted from
- Isolation and purification of UDP-glucuronosyltransferases (1990), Chem. Res. Toxicol., 3, 509-516.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| bilirubin | stimulates the glucoronidation of 4-nitrophenol and morphine | Rattus norvegicus |  |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| different isozymes expressed in COS-7 | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-nitrophenol glucuronide | inhibits 4-nitrophenol glucuronidation | Rattus norvegicus | |
| codeine | competitive inhibitor to morphine-UDPGT | Rattus norvegicus | |
| cyproheptadine | - |
Rattus norvegicus | |
| desmethylcyproheptadine | - |
Rattus norvegicus | |
| flunitrazepam | competitive inhibitor to morphine glucuronidation | Rattus norvegicus | |
| morphine 3-glucuronide | inhibits morphine glucuronidation | Rattus norvegicus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| endoplasmic reticulum | - |
Homo sapiens | 5783 | - |
| endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
| microsome | - |
Homo sapiens | - |
- |
| microsome | - |
Rattus norvegicus | - |
- |
| microsome | - |
Oryctolagus cuniculus | - |
- |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50000 | - |
x * 50000, 17beta-hydroxysteroid-UDPGT | Rattus norvegicus |
| 52000 | - |
x * 52000, 3alpha-hydroxysteroid-UDPGT | Rattus norvegicus |
| 53000 | - |
x * 53000 estriol-UDPGT | Homo sapiens |
| 56000 | - |
x * 56000, morphine-UDPGT | Rattus norvegicus |
| 56000 | - |
x * 56000, 4-nitrophenol-UDPGT | Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | Homo sapiens | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
| additional information | Rattus norvegicus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
| additional information | Oryctolagus cuniculus | elimination of lipid-soluble endogenous compounds and xenobiotics | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
overview | - |
| Oryctolagus cuniculus | - |
rabbit | - |
| Rattus norvegicus | - |
overview | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| method | Rattus norvegicus |
| method | Oryctolagus cuniculus |
| two isozymes purified with chromatofocusing and UDP-hexanolamine Sepharose 4B affinity chromatography | Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| estriol + UDPglucuronate | - |
Homo sapiens | UDP + estriol-16 alpha-glucuronide | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Homo sapiens | ? | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Rattus norvegicus | ? | - |
? | |
| additional information | elimination of lipid-soluble endogenous compounds and xenobiotics | Oryctolagus cuniculus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 56000, morphine-UDPGT | Rattus norvegicus |
| ? | x * 56000, 4-nitrophenol-UDPGT | Rattus norvegicus |
| ? | x * 52000, 3alpha-hydroxysteroid-UDPGT | Rattus norvegicus |
| ? | x * 53000 estriol-UDPGT | Homo sapiens |
| ? | all values determined by SDS-PAGE | Homo sapiens |
| ? | all values determined by SDS-PAGE | Rattus norvegicus |
| ? | all values determined by SDS-PAGE | Oryctolagus cuniculus |
| ? | x * 50000, 17beta-hydroxysteroid-UDPGT | Rattus norvegicus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.08 | - |
cyproheptadine | morphine-UDPGT | Rattus norvegicus | |
| 1.3 | - |
FNZ | - |
Rattus norvegicus | |
| 4 | - |
desmethylcyproheptadine | - |
Rattus norvegicus | |
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