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Literature summary for 2.4.1.17 extracted from
- Phospholipid dependency of purified estrone and p-nitrophenol UDP-glucuronyltransferases (1980), Life Sci., 27, 2471-2476.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| choline | required as phospholipid with a polar head group for maximal activity | Oryctolagus cuniculus |  |
| Lecithins | activation, unsaturated lecithins are more efficient than saturated restoring estrone-UDPG activity whereas saturated lecithins are more efficient than unsaturated in restoring 4-nitrophenol-UDPG activity | Oryctolagus cuniculus | |
| Phospholipids | estrone UDP-glucuronosyltransferase is inactive in absence of phospholipids, 300fold stimulation by phospholipids. 4-nitrophenol UDP-glucuronosyltransferase is active in absence of phospholipids, but stimulated between 3fold and 4fold in their presence | Oryctolagus cuniculus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | - |
Oryctolagus cuniculus | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Oryctolagus cuniculus | - |
rabbit | - |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Oryctolagus cuniculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenol + UDP-glucuronate | - |
Oryctolagus cuniculus | 4-nitrophenyl beta-D-glucuronide + UDP | - |
? | |
| estrone + UDPglucuronate | - |
Oryctolagus cuniculus | UDP + estrone 3-O-glucuronide | - |
? | |
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